Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | METAP2 | P50579 | 9/20 | 0.49 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.48 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10410665 | 0.89 | EGLN1 (0.51) | MEN1KMT2ANPC1RAB9AMETAP2 | |
| SCHEMBL6410939 | 0.80 | HSD11B1 (0.53) | MEN1KMT2ANPC1RAB9AMETAP2 | |
| SCHEMBL30719359 | 0.80 | MEN1 (0.50) | MEN1KMT2ANPC1RAB9AMETAP2 | |
| SCHEMBL10409188 | 0.80 | HSD11B1 (0.47) | METAP2HSD11B1HDAC8HDAC6 | |
| SCHEMBL15367173 | 0.78 | METAP2 (0.49) | MEN1KMT2ANPC1RAB9AMETAP2 | |
| SCHEMBL9361258 | 0.78 | METAP2 (0.49) | MEN1KMT2ANPC1RAB9AMETAP2 | |
| SCHEMBL20103215 | 0.77 | EGLN1 (0.48) | MEN1KMT2ANPC1RAB9AMETAP2 | |
| SCHEMBL31150920 | 0.77 | HSD11B1 (0.50) | MEN1KMT2ANPC1RAB9AMETAP2 | |
| SCHEMBL18208793 | 0.77 | EGLN1 (0.45) | MEN1KMT2ANPC1RAB9AMETAP2 | |
| SCHEMBL24203882 | 0.76 | EGLN1 (0.47) | MEN1KMT2ANPC1RAB9AMETAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4963691-A | Spirodilactam derivatives | SHELL OIL COMPANY (US) | 1990-10-16 | — | — | US | claimed |
| US-4963691-A | Spirodilactam derivatives | SHELL OIL COMPANY (US) | 1990-10-16 | — | — | US | disclosed |