Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.67 |
| ▸ | ATM | Q13315 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.50 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10409505 | 0.98 | KCNH2 (0.67) | KCNH2KDM4EATMALDH1A1CHRNB2 | |
| SCHEMBL29413774 | 0.85 | KDM4E (0.84) | KCNH2KDM4ESMN1; SMN2KMT2A | |
| SCHEMBL1023508 | 0.85 | KDM4E (0.84) | KCNH2KDM4ESMN1; SMN2KMT2A | |
| SCHEMBL12885024 | 0.78 | KDM4E (0.69) | KCNH2KDM4EATMALDH1A1LMNA | |
| SCHEMBL13261015 | 0.78 | KDM4E (0.64) | KCNH2KDM4EATMALDH1A1LMNA | |
| SCHEMBL14924417 | 0.75 | KCNH2 (0.67) | KCNH2KDM4EALDH1A1CHRNB2CHRNA4 | |
| SCHEMBL14923990 | 0.75 | CHRNB2 (0.51) | KCNH2KDM4EALDH1A1CHRNB2CHRNA4 | |
| SCHEMBL1548013 | 0.74 | KDM4E (0.58) | KCNH2KDM4EALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL17383765 | 0.74 | KCNH2 (0.56) | KCNH2ALDH1A1CHRNB2CHRNA4LMNA | |
| SCHEMBL20503253 | 0.74 | KDM4E (0.63) | KCNH2KDM4EALDH1A1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4895840-A | ANTIARRHYTHMIA AGENTS | A. H. ROBINS COMPANY, INCORPORATED (US) | 1990-01-23 | — | — | US | disclosed |
| EP-0295010-A1 | Derivatives of alkylaminoalkyl ureas and cyanoguanidines | A.H. ROBINS COMPANY, INCORPORATED (US) | 1988-12-14 | — | — | EP | disclosed |