Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10409483 | 0.91 | SLC6A2 (0.40) | CYP2D6SLC6A2SLC6A4SLC6A3TAAR1 | |
| SCHEMBL6867873 | 0.87 | DPP4 (0.42) | SIGMAR1SLC6A2SLC6A4SLC6A3DPP4 | |
| SCHEMBL11835662 | 0.86 | ADRB2 (0.35) | SIGMAR1CYP2D6DPP4DPP7 | |
| SCHEMBL10958845 | 0.85 | SLC18A3 (0.39) | SIGMAR1CYP2D6SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL27843488 | 0.84 | SLC6A2 (0.41) | SIGMAR1CYP2D6SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL27506411 | 0.84 | TAAR1 (0.44) | SIGMAR1CYP2D6SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL5323955 | 0.83 | HSD17B10 (0.46) | SIGMAR1 | |
| SCHEMBL4977025 | 0.82 | SLC18A3 (0.44) | CYP2D6SLC6A2SLC6A4SLC6A3TAAR1 | |
| SCHEMBL404339 | 0.82 | TAAR1 (0.44) | CYP2D6SLC6A2SLC6A4SLC6A3TAAR1 | |
| SCHEMBL8757950 | 0.79 | TAAR1 (0.41) | TAAR1DPP4DPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4895840-A | ANTIARRHYTHMIA AGENTS | A. H. ROBINS COMPANY, INCORPORATED (US) | 1990-01-23 | — | — | US | disclosed |
| EP-0295010-A1 | Derivatives of alkylaminoalkyl ureas and cyanoguanidines | A.H. ROBINS COMPANY, INCORPORATED (US) | 1988-12-14 | — | — | EP | disclosed |