Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | MGLL | Q99685 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14062973 | 0.82 | ALDH1A1 (0.54) | TDP1MEN1KMT2ACYP2C19ALDH1A1 | |
| SCHEMBL9614229 | 0.81 | MEN1 (0.44) | TDP1MEN1KMT2ACYP2C19ALDH1A1 | |
| SCHEMBL9972152 | 0.80 | MEN1 (0.41) | TDP1MEN1KMT2ACYP2C19ALDH1A1 | |
| SCHEMBL11637675 | 0.79 | CTSL (0.45) | MEN1KMT2ACYP2C19HCRTR2TSHR | |
| SCHEMBL11635684 | 0.79 | CTSL (0.45) | MEN1KMT2ACYP2C19HCRTR2TSHR | |
| SCHEMBL12369625 | 0.79 | MEN1 (0.43) | TDP1MEN1KMT2ACYP2C19HCRTR2 | |
| SCHEMBL1560842 | 0.79 | CTSL (0.45) | MEN1KMT2ACYP2C19HCRTR2TSHR | |
| SCHEMBL13118628 | 0.78 | MEN1 (0.42) | TDP1MEN1KMT2ACYP2C19ALDH1A1 | |
| SCHEMBL16826894 | 0.78 | MEN1 (0.42) | TDP1MEN1KMT2ACYP2C19ALDH1A1 | |
| SCHEMBL3543684 | 0.78 | MEN1 (0.42) | TDP1MEN1KMT2ACYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4977273-A | RADIATION-SENSITIZING ANTITUMOR AGENTS | Kyoto University of Honmachi (JP) | 1990-12-11 | — | — | US | disclosed |
| EP-0373630-A1 | Novel fluorine-containing 2-nitroimidazole derivatives and radiosensitizer comprising the same | KYOTO UNIVERSITY (JP) | 1990-06-20 | — | — | EP | disclosed |