Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 17/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.65 |
| ▸ | ATXN2 | Q99700 | 10/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL104127 | 0.87 | ENPP2 (0.83) | ENPP2KCNH2ATXN2 | |
| SCHEMBL104877 | 0.81 | ENPP2 (0.55) | ENPP2KCNH2ATXN2 | |
| SCHEMBL105919 | 0.80 | ENPP2 (0.77) | ENPP2KCNH2ATXN2KDM4EALDH1A1 | |
| SCHEMBL172193 | 0.80 | ENPP2 (0.72) | ENPP2KCNH2ATXN2KDM4EALDH1A1 | |
| SCHEMBL103926 | 0.79 | ENPP2 (0.48) | ENPP2KCNH2ATXN2KDM4EALDH1A1 | |
| SCHEMBL3054811 | 0.79 | ENPP2 (1.00) | ENPP2KCNH2ATXN2 | |
| SCHEMBL108790 | 0.77 | ENPP2 (0.58) | ENPP2KCNH2ATXN2KDM4EALDH1A1 | |
| SCHEMBL106235 | 0.77 | ENPP2 (0.67) | ENPP2KCNH2ATXN2KDM4EALDH1A1 | |
| SCHEMBL2549777 | 0.75 | KDM4E (0.59) | ENPP2KCNH2KDM4EALDH1A1 | |
| SCHEMBL1671586 | 0.74 | ENPP2 (0.48) | ENPP2KCNH2ATXN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2426106-B1 | Piperidine and Piperazine derivatives for the treatment of tumours | MERCK PATENT GMBH (DE) | 2013-07-31 | — | — | EP | claimed |
| EP-2426106-A1 | Piperidine and Piperazine derivatives for the treatment of tumours | Merck Patent GmbH (DE) | 2012-03-07 | — | — | EP | claimed |
| EP-2426106-B1 | Piperidine and Piperazine derivatives for the treatment of tumours | MERCK PATENT GMBH (DE) | 2013-07-31 | — | — | EP | disclosed |
| EP-2426106-A1 | Piperidine and Piperazine derivatives for the treatment of tumours | Merck Patent GmbH (DE) | 2012-03-07 | — | — | EP | disclosed |