Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 2/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.66 |
| ▸ | TSHR | P16473 | 1/20 | 0.66 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.66 |
| ▸ | MTOR | P42345 | 1/20 | 0.66 |
| ▸ | RAB9A | P51151 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.65 |
| ▸ | MEN1 | O00255 | 2/20 | 0.65 |
| ▸ | BLM | P54132 | 1/20 | 0.65 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | DRD2 | P14416 | 3/20 | 0.50 |
| ▸ | DRD3 | P35462 | 3/20 | 0.50 |
| ▸ | CNR1 | P21554 | 1/20 | 0.49 |
| ▸ | CNR2 | P34972 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | HRH2 | P25021 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10509599 | 0.88 | FAAH (0.64) | FAAHCYP3A4CYP2D6TSHRALOX12 | |
| Hydrochloric Acid SCHEMBL10510024 | 0.87 | KMT2A (0.81) | FAAHCYP3A4CYP2D6TSHRALOX12 | |
| Amperozide SCHEMBL340961 | 0.80 | CYP3A4 (1.00) | FAAHCYP3A4CYP2D6TSHRALOX12 | |
| Amperozide SCHEMBL1321270 | 0.79 | MEN1 (1.00) | FAAHCYP3A4CYP2D6TSHRALOX12 | |
| Amperozide SCHEMBL17360644 | 0.78 | CYP3A4 (0.95) | FAAHCYP3A4CYP2D6TSHRALOX12 | |
| SCHEMBL9809310 | 0.78 | HRH1 (0.69) | FAAHCYP3A4CYP2D6TSHRALOX12 | |
| Hydrochloric Acid SCHEMBL10415232 | 0.78 | FAAH (0.63) | FAAHCYP3A4CYP2D6TSHRALOX12 | |
| SCHEMBL10415796 | 0.78 | HRH1 (0.65) | FAAHCYP3A4CYP2D6TSHRALOX12 | |
| Hydrochloric Acid SCHEMBL10510286 | 0.76 | MEN1 (0.83) | FAAHCYP3A4CYP2D6TSHRALOX12 | |
| SCHEMBL27320487 | 0.76 | KDM4E (0.52) | KDM4ESLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4935419-A | For psychosis and depression | KABI PHARMACIA AKTIEBOLAG (SE) | 1990-06-19 | — | — | US | disclosed |
| EP-0136274-B1 | 1-PIPERAZINE CARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS | AB Ferrosan (SE) | 1989-11-08 | — | — | EP | disclosed |
| EP-0136274-A1 | 1-Piperazine carboxamide derivatives, their preparation and their use in pharmaceutical compositions | AB Ferrosan (SE) | 1985-04-03 | — | — | EP | disclosed |
| WO-1985000811-A1 | NOVEL 1-PIPERAZINECARBOXAMIDE DERIVATIVES | AB FERROSAN (SE) | 1985-02-28 | — | — | WO | disclosed |