Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | GLA | P06280 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.55 |
| ▸ | ACHE | P22303 | 1/20 | 0.54 |
| ▸ | THRB | P10828 | 2/20 | 0.52 |
| ▸ | DRD4 | P21917 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL10414741 | 1.00 | MAPT (0.55) | MAPTL3MBTL1KDM4EALDH1A1GLA | |
| SCHEMBL10483079 | 0.91 | MAPT (0.62) | MAPTL3MBTL1KDM4EALDH1A1GLA | |
| Fumaric Acid SCHEMBL10415373 | 0.88 | GAA (0.54) | L3MBTL1KDM4EALDH1A1GAAACHE | |
| Fumaric Acid SCHEMBL10415374 | 0.88 | GAA (0.54) | L3MBTL1KDM4EALDH1A1GAAACHE | |
| Fumaric Acid SCHEMBL10415652 | 0.88 | ACHE (0.52) | MAPTL3MBTL1KDM4EACHETHRB | |
| Fumaric Acid SCHEMBL10415651 | 0.88 | ACHE (0.52) | MAPTL3MBTL1KDM4EACHETHRB | |
| Fumaric Acid SCHEMBL10414135 | 0.87 | MEN1 (0.52) | L3MBTL1GAAACHE | |
| Fumaric Acid SCHEMBL10414137 | 0.87 | MEN1 (0.52) | L3MBTL1GAAACHE | |
| Fumaric Acid SCHEMBL10416136 | 0.86 | ACHE (0.49) | L3MBTL1ACHETHRBDRD2SIGMAR1 | |
| Fumaric Acid SCHEMBL10415380 | 0.86 | CCR3 (0.52) | L3MBTL1ACHEDRD2SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4945096-A | Treatment of a depressive state with 2-[(4-piperidyl)methyl]-1,2,3,4-tetrahydroisoquinoline derivates | SYNTHELABO (FR) | 1990-07-31 | — | — | US | disclosed |
| US-4885302-A | 2-((4-Piperidyl)methyl)-1,2,3,4-tetrahydroisoquinoline derivatives, their preparation and their application in therapy | SYNTHELABO, 58, RUE DE LA GLACIERE - 75013 PARIS | 1989-12-05 | — | — | US | disclosed |