Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.58 |
| ▸ | F10 | P00742 | 2/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.45 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL10415652 | 0.91 | ACHE (0.52) | ACHEF10PRMT5WDR77L3MBTL1 | |
| Fumaric Acid SCHEMBL10415651 | 0.91 | ACHE (0.52) | ACHEF10PRMT5WDR77L3MBTL1 | |
| SCHEMBL7540594 | 0.86 | ACHE (0.76) | ACHEHTR1ASIGMAR1PRMT5WDR77 | |
| SCHEMBL8304595 | 0.86 | L3MBTL1 (0.55) | ACHESIGMAR1L3MBTL1KDM4EALDH1A1 | |
| SCHEMBL10483079 | 0.86 | MAPT (0.62) | ACHEHTR1ASIGMAR1PRMT5WDR77 | |
| Hydrochloric Acid SCHEMBL10415385 | 0.85 | ACHE (0.74) | ACHEHTR1ASIGMAR1PRMT5WDR77 | |
| Hydrochloric Acid SCHEMBL6968014 | 0.85 | L3MBTL1 (0.54) | ACHESIGMAR1L3MBTL1KDM4EALDH1A1 | |
| SCHEMBL12533238 | 0.83 | MEN1 (0.51) | F10KDM4EGAA | |
| SCHEMBL10416145 | 0.83 | ACHE (0.55) | ACHEHTR1ASIGMAR1PRMT5WDR77 | |
| SCHEMBL10414142 | 0.82 | MEN1 (0.67) | ACHESIGMAR1KDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4945096-A | Treatment of a depressive state with 2-[(4-piperidyl)methyl]-1,2,3,4-tetrahydroisoquinoline derivates | SYNTHELABO (FR) | 1990-07-31 | — | — | US | disclosed |
| US-4885302-A | 2-((4-Piperidyl)methyl)-1,2,3,4-tetrahydroisoquinoline derivatives, their preparation and their application in therapy | SYNTHELABO, 58, RUE DE LA GLACIERE - 75013 PARIS | 1989-12-05 | — | — | US | disclosed |