Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 16/20 | 0.68 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.55 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.55 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.55 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.54 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.52 |
| ▸ | ABL1 | P00519 | 1/20 | 0.51 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.51 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10416823 | 0.92 | OPRM1 (0.62) | OPRM1HSD11B1OPRL1OPRD1OPRK1 | |
| SCHEMBL10415393 | 0.89 | OPRM1 (0.62) | OPRM1HSD11B1OPRL1OPRD1OPRK1 | |
| SCHEMBL11031960 | 0.87 | OPRM1 (0.62) | OPRM1HSD11B1OPRL1OPRD1OPRK1 | |
| SCHEMBL10416334 | 0.87 | OPRM1 (0.61) | OPRM1HSD11B1OPRL1OPRD1OPRK1 | |
| SCHEMBL10416916 | 0.87 | OPRM1 (0.56) | OPRM1HSD11B1OPRL1OPRD1OPRK1 | |
| SCHEMBL10416914 | 0.85 | OPRM1 (0.49) | OPRM1OPRL1OPRD1OPRK1PAX8 | |
| SCHEMBL10416818 | 0.84 | ADRA1D (0.69) | OPRM1HSD11B1OPRL1OPRD1OPRK1 | |
| SCHEMBL11033261 | 0.83 | OPRM1 (0.60) | OPRM1HSD11B1OPRL1OPRD1OPRK1 | |
| SCHEMBL31422682 | 0.83 | OPRM1 (0.75) | OPRM1OPRL1OPRD1OPRK1 | |
| Hydrochloric Acid SCHEMBL11033620 | 0.83 | OPRM1 (0.60) | OPRM1OPRL1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4902799-A | HYPOTENSIVE, HYPOLIPEMIC, ANTIANOXIC, SPASMOLYTIC, PLATELET AGGREGATION INHIBITING, ANTITHROMBOTIC, CALCIUM ANTAGONIZING, NEUROLEPTIC AGENTS | MAGGIONI-WINTHROP S.P.A. (IT) | 1990-02-20 | — | — | US | claimed |
| WO-1987002666-A2 | BICYCLIC ALKOXY- AND ALKYLTHIO-SUBSTITUTED AMINOALCOHOLS | MAGGIONI-WINTHROP S.P.A. (IT) | 1987-05-07 | — | — | WO | claimed |