Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.47 |
| ▸ | CYP1A1 | P04798 | 5/20 | 0.47 |
| ▸ | CYP1B1 | Q16678 | 5/20 | 0.47 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL87841 | 1.00 | CA12 (0.47) | CA12CA9CYP1A2CYP1A1CYP1B1 | |
| SCHEMBL29756136 | 1.00 | CA12 (0.47) | CA12CA9CYP1A2CYP1A1CYP1B1 | |
| Biphenyl SCHEMBL27372808 | 0.93 | CYP1A2 (0.52) | CA12CA9CYP1A2CYP1A1CYP1B1 | |
| SCHEMBL372269 | 0.91 | HPRT1 (0.47) | CA12CA9CYP1A2CYP1A1CYP1B1 | |
| Phosphoric Acid SCHEMBL31540356 | 0.91 | CA12 (0.44) | CA12CA9CYP1A2CYP1A1CYP1B1 | |
| Phenol SCHEMBL28029036 | 0.91 | CYP1A2 (0.44) | CA12CA9CYP1A2CYP1A1CYP1B1 | |
| Toluene SCHEMBL8134407 | 0.91 | CYP1A2 (0.45) | CA12CA9CYP1A2CYP1A1CYP1B1 | |
| SCHEMBL3835395 | 0.88 | MTNR1A (0.48) | CA12CA9CYP1A2CYP1A1CYP1B1 | |
| SCHEMBL31391373 | 0.88 | MTNR1A (0.48) | CA12CA9CYP1A2CYP1A1CYP1B1 | |
| Benzofuran SCHEMBL8050244 | 0.88 | CYP1A2 (0.42) | CA12CA9CYP1A2CYP1A1CYP1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11874434-B2 | Ophthalmic devices comprising photochromic materials with reactive substituents | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2024-01-16 | — | — | US | disclosed |
| US-20220137262-A1 | OPHTHALMIC DEVICES COMPRISING PHOTOCHROMIC MATERIALS WITH REACTIVE SUBSTITUENTS | JOHNSON & JOHNSON VISION CARE (US) | 2022-05-05 | — | — | US | disclosed |
| US-11256002-B2 | Ophthalmic devices comprising photochromic materials with reactive substituents | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2022-02-22 | — | — | US | disclosed |
| US-20200131193-A1 | PYRANOQUINAZOLINE DERIVATIVES AND NAPHTHOPYRAN DERIVATIVES | KANTO KAGAKU KABUSHIKI KAISHA (JP) | 2020-04-30 | — | — | US | disclosed |
| EP-3633423-A1 | OPHTHALMIC DEVICES COMPRISING PHOTOCHROMIC MATERIALS WITH REACTIVE SUBSTITUENTS | Johnson & Johnson Vision Care, Inc. (US) | 2020-04-08 | — | — | EP | disclosed |
| CN-104898187-B | Ophthalmic devices comprising photochromic materials having reactive substituents | INNOTECH, INC., JOHNSON AND JOHNSON VISION CARE (US) | 2019-12-10 | — | — | CN | disclosed |
| EP-1872159-B1 | OPHTHALMIC DEVICES COMPRISING PHOTOCHROMIC MATERIALS WITH REACTIVE SUBSTITUENTS | JOHNSON AND JOHNSON VISION CARE INC (US) | 2019-09-04 | — | — | EP | disclosed |
| US-20190129067-A1 | OPHTHALMIC DEVICES COMPRISING PHOTOCHROMIC MATERIALS WITH REACTIVE SUBSTITUENTS | JOHNSON & JOHNSON VISION CARE (US) | 2019-05-02 | — | — | US | disclosed |
| US-10197707-B2 | Ophthalmic devices comprising photochromic materials with reactive sub substituents | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2019-02-05 | — | — | US | disclosed |
| US-20150241601-A1 | OPHTHALMIC DEVICES COMPRISING PHOTOCHROMIC MATERIALS WITH REACTIVE SUBSTITUENTS | JOHNSON & JOHNSON VISION CARE (US) | 2015-08-27 | — | — | US | disclosed |
| US-9052438-B2 | Ophthalmic devices comprising photochromic materials with reactive substituents | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2015-06-09 | — | — | US | disclosed |
| EP-2270559-A2 | Ophthalmic devices comprising photochromic materials with reactive substituents | Johnson and Johnson Vision Care, Inc. (US) | 2011-01-05 | — | — | EP | disclosed |
| EP-1866699-B1 | PHOTOCHROMIC MATERIALS WITH REACTIVE SUBSTITUENTS | TRANSITIONS OPTICAL INC (US) | 2010-05-05 | — | — | EP | disclosed |
| US-7556750-B2 | Photochromic materials with reactive substituents | TRANSITIONS OPTICAL, INC. (US) | 2009-07-07 | — | — | US | disclosed |
| EP-1866699-A1 | PHOTOCHROMIC MATERIALS WITH REACTIVE SUBSTITUENTS | TRANSITIONS OPTICAL, INC. (US) | 2007-12-19 | — | — | EP | disclosed |
| WO-2006110219-A1 | PHOTOCHROMIC MATERIALS WITH REACTIVE SUBSTITUENTS | TRANSITIONS OPTICAL, INC. (US) | 2006-10-19 | — | — | WO | disclosed |
| US-20060226401-A1 | Ophthalmic devices comprising photochromic materials with reactive substituents | JOHNSON & JOHNSON VISION CARE, INC. | 2006-10-12 | — | — | US | disclosed |
| US-20060226400-A1 | Photochromic materials with reactive substituents | TRANSITIONS OPTICAL LIMITED (IE) | 2006-10-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200131193-A1 | PYRANOQUINAZOLINE DERIVATIVES AND NAPHTHOPYRAN DERIVATIVES | PPOX, TYR, NQO1 | CA12 2734/4885CA9 2130/4885CYP1A2 86/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.