SCHEMBL10420488

SCHEMBL10420488

Cc1cc(C(=O)COc2ccccc2)cc(C(=O)O)c1O

nearest known ligand 0.46

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.46
LMNA P02545 2/20 0.46
GAA P10253 1/20 0.46
KMT2A Q03164 5/20 0.46
MEN1 O00255 4/20 0.46
NPC1 O15118 3/20 0.46
RAB9A P51151 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
HMGB1 P09429 1/20 0.45
CXCL12 P48061 1/20 0.45
ALOX15 P16050 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.43
CASP3 P42574 1/20 0.42
CASP7 P55210 1/20 0.42
CASP9 P55211 1/20 0.42
CTH P32929 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10422108 0.78 MCL1 (0.51) MAPTLMNAKMT2AMEN1NPC1
SCHEMBL10420496 0.78 HMGB1 (0.53) MAPTLMNAGAAKMT2AMEN1
SCHEMBL11549496 0.78 MAPT (0.71) MAPTLMNAGAAKMT2AMEN1
SCHEMBL9385176 0.76 HMGB1 (0.46) MAPTKMT2AMEN1NPC1HMGB1
SCHEMBL9508765 0.74 HMGB1 (0.54) MAPTKMT2AMEN1NPC1HMGB1
SCHEMBL10421181 0.74 KMT2A (0.51) MAPTGAAKMT2AMEN1HMGB1
SCHEMBL11620046 0.73 HMGB1 (0.53) MAPTKMT2AMEN1NPC1SMN1; SMN2
SCHEMBL1068092 0.73 MAPT (0.69) MAPTLMNAKMT2AMEN1NPC1
SCHEMBL17119987 0.72 KMT2A (0.55) MAPTLMNAKMT2AMEN1NPC1
SCHEMBL15214369 0.72 ALOX15 (0.55) MAPTLMNAKMT2AMEN1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4918047-A CONTAINING OXYSALICYLIC ACID DERIVATIVE AND ZINC COMPOUND FUJI PHOTO FILM CO., LTD. (JP) 1990-04-17 US disclosed
EP-0253666-A2 Heat-sensitive recording material containing dye-forming components FUJI PHOTO FILM CO., LTD. (JP) 1988-01-20 EP disclosed