Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX12 | P18054 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | RAPGEF3 | O95398 | 15/20 | 0.47 |
| ▸ | RAPGEF4 | Q8WZA2 | 8/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NPY1R | P25929 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPY2R | P49146 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10421664 | 1.00 | ALOX12 (0.48) | ALOX12MEN1KMT2ARAPGEF3RAPGEF4 | |
| SCHEMBL10421616 | 0.95 | ALOX12 (0.50) | ALOX12MEN1KMT2ARAPGEF3RAPGEF4 | |
| SCHEMBL10421615 | 0.95 | ALOX12 (0.50) | ALOX12MEN1KMT2ARAPGEF3RAPGEF4 | |
| SCHEMBL10420084 | 0.85 | RAPGEF3 (0.52) | ALOX12MEN1KMT2ARAPGEF3RAPGEF4 | |
| SCHEMBL10420082 | 0.85 | RAPGEF3 (0.52) | ALOX12MEN1KMT2ARAPGEF3RAPGEF4 | |
| SCHEMBL10675097 | 0.84 | RAPGEF3 (0.43) | ALOX12MEN1KMT2ARAPGEF3RAPGEF4 | |
| SCHEMBL10675101 | 0.84 | RAPGEF3 (0.43) | ALOX12MEN1KMT2ARAPGEF3RAPGEF4 | |
| SCHEMBL5563751 | 0.82 | RAPGEF3 (0.54) | ALOX12MEN1KMT2ARAPGEF3RAPGEF4 | |
| SCHEMBL5563754 | 0.82 | RAPGEF3 (0.54) | ALOX12MEN1KMT2ARAPGEF3RAPGEF4 | |
| SCHEMBL10420125 | 0.81 | MEN1 (0.43) | ALOX12MEN1KMT2ARAPGEF3RAPGEF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0170316-B1 | ALPHA-ARYL-4-(4,5-DIHYDRO-3,5-DIOXO-1,2,4-TRIAZIN-2(3H)-YL)BENZENEACETONITRILES | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-05-30 | — | — | EP | disclosed |
| EP-0170316-A2 | alpha-Aryl-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)benzeneacetonitriles | JANSSEN PHARMACEUTICA N.V. (BE) | 1986-02-05 | — | — | EP | disclosed |