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Sugi Predict / Targets / RAPGEF3

RAPGEF3

Rap guanine nucleotide exchange factor 3 · O95398 · RAPGEF3 on Sugi Atlas →

5,964 patent compounds predicted against RAPGEF3, 3,022 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL5563751 SCHEMBL5563751 0.54 19/20
SCHEMBL5563754 SCHEMBL5563754 0.54 19/20
SCHEMBL5823972 SCHEMBL5823972 0.56 12/20
SCHEMBL3678595 SCHEMBL3678595 0.65 11/20
SCHEMBL8745992 SCHEMBL8745992 0.52 11/20
SCHEMBL8066578 SCHEMBL8066578 0.54 9/20
SCHEMBL923266 SCHEMBL923266 0.48 9/20
SCHEMBL6545507 SCHEMBL6545507 0.41 9/20
Carbonyl Cyanide M-Chlorophenylhydrazone Carbonyl Cyanide M-Chlorophenylhydrazone (SCHEMBL379195) 0.52 8/20
SCHEMBL6812202 SCHEMBL6812202 0.53 7/20
SCHEMBL6812204 SCHEMBL6812204 0.53 7/20
SCHEMBL6470635 SCHEMBL6470635 0.46 7/20
SCHEMBL6470640 SCHEMBL6470640 0.46 7/20
SCHEMBL3129088 SCHEMBL3129088 0.43 7/20
SCHEMBL2343565 SCHEMBL2343565 0.50 6/20
SCHEMBL4792259 SCHEMBL4792259 0.44 6/20
SCHEMBL8064858 SCHEMBL8064858 0.44 6/20
SCHEMBL922712 SCHEMBL922712 0.54 5/20
SCHEMBL922713 SCHEMBL922713 0.54 5/20
SCHEMBL1858924 SCHEMBL1858924 0.48 5/20

Clinical trials — most relevant to RAPGEF3 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
The Phosphodiesterase 4 Inhibitor Roflumilast as an Adjunct to Antidepressants in Major Depressive Disorder Patients PHASE1/PHASE2WITHDRAWN
Theophylline Treatment for Pseudohypoparathyroidism - Children 2-12 Years Old PHASE2ACTIVE_NOT_RECRUITING
Pentoxifylline as an Adjunctive in Treatment of Negative Symptoms in Chronic Schizophrenia PHASE1/PHASE2COMPLETED
Temsirolimus and Sorafenib in Advanced Hepatocellular Carcinoma PHASE1COMPLETED
FAK Inhibitor in Patients With Advanced Solid Tumors PHASE1NOT_YET_RECRUITING
Pre-Surgical Trial of the Combination of Metformin and Atorvastatin in Newly Diagnosed Operable Breast Cancer EARLY_PHASE1COMPLETED
ADRB3, ROCK2 and GEF Levels in Overactive Bladder Patients nanCOMPLETED
Study of the Pathophysiological Mechanisms Involved in Bleeding Events nanCOMPLETED
Investigating the Genetic Basis of Pseudoexfoliation Syndrome, Angle-closure Glaucoma and Primary Open-angle Glaucoma nanRECRUITING
Autophagy in Systemic Lupus Erythematosus nanUNKNOWN
Genetic Characterization of Parkinson's Disease nanCOMPLETED
NCF Gene & TNFSF4 in SLE Patients nanUNKNOWN
The Phosphodiesterase-3 Inhibitor Cilostazol as an Adjunctive to Antidepressants in Patients With Major Depressive Disorder. nanCOMPLETED
Intravenous Terbutaline in Severe Status Asthmaticus nanUNKNOWN
Glycine and Magnesium+Thiamine for the Treatment of Primary Ciliary Dyskinesia nanRECRUITING
Evaluation of Vasopressin in the Vessels of Ovarian Neoplasms nanCOMPLETED
Inflammatory Genomics in Human Carotid Artery Disease nanCOMPLETED
Genetics and Psychopathology in the 22q11 Deletion Syndrome nanUNKNOWN
Biomarkers of CASH nanACTIVE_NOT_RECRUITING
The Genetic Study of Primary Angle-Closure Glaucoma nanUNKNOWN
Genetic Analysis of Familial Cases of Premature Ovarian Failure nanCOMPLETED
Immune Cell Response to Stimuli nanRECRUITING
The Influence of Genetic Variations in ELAPOR1 or ELAPOR2 on Insulin Secretion and Glucose Regulation in Humans nanUNKNOWN
Effect of Intraperitoneal Bupivacaine with Dexmedotomidine or Fentanyl for Post-Operative Analgesia Following Laparoscopy in Pediatric Patients nanNOT_YET_RECRUITING
The Association Between Post-ERCP Acute Pancreatitis and Various Genetic Mutations nanCOMPLETED
Changes in Skin Innervation of Neurologically Asymptomatic Type 2 Diabetic Patients: the Correlation With the Diabetic Parameters and Neurotrophins. nanUNKNOWN
New Genes Involved in Molecular Etiology of Rett Syndrome Through DNA Microarray Comparative Genomic Hybridization nanCOMPLETED
The Roles of Neutrophil Elastase in Lung Cancer nanUNKNOWN
Evaluation the Topical Apremilast Nanoformulation in Treatment of Localized Plaque Psoriasis nanNOT_YET_RECRUITING
Genetic Analysis of Familial Melanoma nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a RAPGEF3 binder may also engage these)

ProteinNameSimilarity
Q8VCC8 — 1.000 Q8VCC8 →
Q9Z1C8 — 1.000 Q9Z1C8 →
Q8K330 — 0.990 Q8K330 →
Q9R117 — 0.990 Q9R117 →
Q9UHV5 — 0.988 Q9UHV5 →
O75064 — 0.988 O75064 →
TYK2 Non-receptor tyrosine-protein kinase TYK2 0.988 landscape →
Q9BRR9 — 0.988 Q9BRR9 →
Q8R2S1 — 0.987 Q8R2S1 →
Q6P112 — 0.987 Q6P112 →
Q562E7 — 0.986 Q562E7 →
Q3U1Y4 — 0.986 Q3U1Y4 →
Q68EF8 — 0.986 Q68EF8 →
P97680 — 0.986 P97680 →
JAK3 Tyrosine-protein kinase JAK3 0.986 landscape →
P0C643 — 0.986 P0C643 →
O15211 — 0.985 O15211 →
Q68DX3 — 0.985 Q68DX3 →
Q99KF0 — 0.985 Q99KF0 →
A4FU01 — 0.985 A4FU01 →
Q9Z1I6 — 0.985 Q9Z1I6 →
Q6ZQA0 — 0.985 Q6ZQA0 →
Q5ND34 — 0.984 Q5ND34 →
Q8TDY4 — 0.984 Q8TDY4 →
A6N9I4 — 0.984 A6N9I4 →
ARHGEF1 Rho guanine nucleotide exchange factor 1 0.984 landscape →
CDC42BPG Serine/threonine-protein kinase MRCK gamma 0.984 landscape →
Q9ESK3 — 0.983 Q9ESK3 →
Q6ZPG2 — 0.983 Q6ZPG2 →
Q8BHW9 — 0.983 Q8BHW9 →