Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
| ▸ | REN | P00797 | 16/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10421152 | 0.88 | APP (0.36) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL10421638 | 0.86 | REN (0.37) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL10421144 | 0.85 | APP (0.35) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL10421167 | 0.84 | PSEN1 (0.38) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL10422409 | 0.81 | REN (0.51) | REN | |
| SCHEMBL9822366 | 0.78 | REN (0.43) | REN | |
| SCHEMBL10422719 | 0.77 | REN (0.47) | REN | |
| SCHEMBL10421176 | 0.77 | REN (0.47) | REN | |
| SCHEMBL7303899 | 0.77 | CTSD (0.42) | REN | |
| SCHEMBL10632103 | 0.75 | CTSD (0.48) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4904660-A | HYPOTENSIVE AGENTS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1990-02-27 | — | — | US | disclosed |