Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 6/20 | 0.64 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.59 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.59 |
| ▸ | HTR1A | P08908 | 4/20 | 0.58 |
| ▸ | DRD2 | P14416 | 3/20 | 0.58 |
| ▸ | HTR2A | P28223 | 3/20 | 0.58 |
| ▸ | DRD3 | P35462 | 3/20 | 0.58 |
| ▸ | DRD1 | P21728 | 1/20 | 0.58 |
| ▸ | DRD5 | P21918 | 1/20 | 0.58 |
| ▸ | HTR2C | P28335 | 2/20 | 0.52 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.52 |
| ▸ | HRH1 | P35367 | 1/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.50 |
| ▸ | HTR7 | P34969 | 2/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10422750 | 1.00 | DRD4 (0.64) | DRD4SIGMAR1TMEM97HTR1ADRD2 | |
| SCHEMBL10422090 | 0.93 | DRD4 (0.67) | DRD4SIGMAR1TMEM97HTR1ADRD2 | |
| SCHEMBL10422093 | 0.93 | DRD4 (0.67) | DRD4SIGMAR1TMEM97HTR1ADRD2 | |
| SCHEMBL10423891 | 0.87 | SIGMAR1 (0.60) | DRD4SIGMAR1HTR1ADRD2HTR2A | |
| SCHEMBL10423890 | 0.87 | SIGMAR1 (0.60) | DRD4SIGMAR1HTR1ADRD2HTR2A | |
| Hydrochloric Acid SCHEMBL10423847 | 0.86 | HTR1A (0.64) | DRD4SIGMAR1TMEM97HTR1ADRD2 | |
| SCHEMBL10422221 | 0.84 | SIGMAR1 (0.59) | DRD4SIGMAR1HTR1ADRD2HTR2A | |
| SCHEMBL10422220 | 0.84 | SIGMAR1 (0.59) | DRD4SIGMAR1HTR1ADRD2HTR2A | |
| SCHEMBL10422111 | 0.84 | AR (0.52) | DRD4SIGMAR1DRD2HTR2ADRD3 | |
| SCHEMBL10422112 | 0.84 | AR (0.52) | DRD4SIGMAR1DRD2HTR2ADRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4931443-A | ANTIPSYCHOTIC AGENTS | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1990-06-05 | — | — | US | disclosed |
| EP-0288575-A1 | PIPERAZINE COMPOUNDS AND THEIR MEDICINAL USE | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1988-11-02 | — | — | EP | disclosed |