Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.33 |
| ▸ | FBP1 | P09467 | 2/20 | 0.32 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10736773 | 0.89 | FDPS (0.40) | FDPSALDH1A1TSHRNOS1HSD17B10 | |
| Bromide SCHEMBL11292435 | 0.87 | FDPS (0.39) | FDPSALDH1A1TSHRNOS1HSD17B10 | |
| Hydrochloric Acid SCHEMBL11728035 | 0.87 | L3MBTL1 (0.40) | FDPSALDH1A1TSHRNOS1HSD17B10 | |
| SCHEMBL10861108 | 0.79 | MAPT (0.33) | FDPSALDH1A1CYP2C19 | |
| SCHEMBL2170936 | 0.75 | — | — | |
| Hydrochloric Acid SCHEMBL17184529 | 0.73 | TSHR (0.39) | FDPSALDH1A1TSHRNOS1HSD17B10 | |
| SCHEMBL8560648 | 0.73 | HRH1 (0.40) | FDPSALDH1A1TSHRNOS1HSD17B10 | |
| Hydrochloric Acid SCHEMBL27275786 | 0.73 | TSHR (0.39) | FDPSALDH1A1TSHRNOS1HSD17B10 | |
| SCHEMBL12854060 | 0.73 | — | — | |
| SCHEMBL11445384 | 0.72 | FDPS (0.42) | FDPSALDH1A1TSHRNOS1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4904792-A | N-thiazolymethylthioalkyl-N'-alkylamidines and related compounds | ELI LILLY AND COMPANY (US) | 1990-02-27 | — | — | US | disclosed |
| US-4760075-A | Miticides | ELI LILLY AND COMPANY (US) | 1988-07-26 | — | — | US | disclosed |
| EP-0091220-B1 | THIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ELI LILLY AND COMPANY (US) | 1987-05-13 | — | — | EP | disclosed |
| US-4474794-A | N-Thiazolylmethylthioalkyl-N1 -alkenyl (or alkynyl)guanidines and related compounds | ELI LILLY AND COMPANY (US) | 1984-10-02 | — | — | US | disclosed |
| EP-0091220-A2 | Thiazole derivatives, process for their preparation and pharmaceutical compositions containing them | ELI LILLY AND COMPANY (US) | 1983-10-12 | — | — | EP | disclosed |
| US-4382090-A | N-Thiazolylmethylthioalkyl-N'alkylamidines and related compounds | ELI LILLY AND COMPANY (US) | 1983-05-03 | — | — | US | disclosed |
| US-4293699-A | CONTAINING A BENZIMIDAZOLE OR 3-/5,6,7,8-TETRAHYDROIMIDAZO(1,5A)PYRIDINE, ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1981-10-06 | — | — | US | disclosed |
| US-4287198-A | ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1981-09-01 | — | — | US | disclosed |
| US-4228291-A | INHIBITORS OF HISTAMINE ACTIVITY | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1980-10-14 | — | — | US | disclosed |
| US-4221802-A | Pharmacologically active guanidine compounds for inhibiting H-2 histamine receptors | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1980-09-09 | — | — | US | disclosed |
| US-4216318-A | HISTAMINE HZ-ANTAGONISTS, ISOCYTOSINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1980-08-05 | — | — | US | disclosed |
| US-4200578-A | ANTIULCER AGENTS, BLOCKING AGENTS, ANTISECRETORY AGENTS | BRISTOL-MYERS COMPANY (US) | 1980-04-29 | — | — | US | disclosed |
| US-4154844-A | ANTIHISTAMINE, GASTRIC JUICE ANTISECRETORY AGENTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1979-05-15 | — | — | US | disclosed |
| US-4154834-A | HETEROCYCLIC-(THIO)ALKYLAMINO SUBSTITUTED-4-PYRIMIDONE OR -THIONES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1979-05-15 | — | — | US | disclosed |
| US-4137237-A | ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1979-01-30 | — | — | US | disclosed |
| US-4070475-A | THIOALKYL-, AMINOALKYL-, AND OXYALKYL- SUBSTITUTED GUANIDINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) | 1978-01-24 | — | — | US | disclosed |
| US-4024271-A | INHIBITORS OF HISTAMINE ACTIVITY | SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) | 1977-05-17 | — | — | US | disclosed |
| US-3950333-A | HISTAMINE INHIBITORS, OXYALKYL, THIOALKYL, AMINOALKYL DERIVATIVES | SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) | 1976-04-13 | — | — | US | disclosed |