Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 7/20 | 0.59 |
| ▸ | ACHE | P22303 | 7/20 | 0.59 |
| ▸ | MAOB | P27338 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | SCN1A | P35498 | 1/20 | 0.48 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.48 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10426021 | 0.83 | BCHE (0.55) | BCHEACHEMAOBKDM4EALDH1A1 | |
| SCHEMBL10426020 | 0.83 | BCHE (0.55) | BCHEACHEMAOBKDM4EALDH1A1 | |
| Bromide SCHEMBL10426109 | 0.83 | BCHE (0.54) | BCHEACHEMAOBKDM4EALDH1A1 | |
| Bromide SCHEMBL10426111 | 0.83 | BCHE (0.54) | BCHEACHEMAOBKDM4EALDH1A1 | |
| SCHEMBL10426725 | 0.82 | BCHE (0.53) | BCHEACHEMAOBKDM4EALDH1A1 | |
| Bromide SCHEMBL10425849 | 0.81 | BCHE (0.53) | BCHEACHEMAOBKDM4EALDH1A1 | |
| SCHEMBL10589183 | 0.81 | KDM4E (0.55) | KDM4EALDH1A1LMNACYP1A2CYP2D6 | |
| SCHEMBL6803941 | 0.79 | KDM4E (0.61) | MAOBKDM4EALDH1A1LMNACYP1A2 | |
| Bromide SCHEMBL10426263 | 0.78 | KDM4E (0.60) | MAOBKDM4EALDH1A1LMNACYP1A2 | |
| SCHEMBL10426054 | 0.77 | ABCB1 (0.52) | KDM4EALDH1A1LMNACYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4906634-A | Novel N-[4-(aminosubstituted)phenyl]methanesulfonamides and their use as cardiovascular agents | SCHERING A.G. (DE) | 1990-03-06 | — | — | US | disclosed |
| EP-0332570-A2 | Novel-N-(4-(Aminosubstituted)phenyl) methanesulfonamides and their use as cardiovascular agents | SCHERING AKTIENGESELLSCHAFT (DE) | 1989-09-13 | — | — | EP | disclosed |