Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 7/20 | 0.54 |
| ▸ | BCHE | P06276 | 7/20 | 0.54 |
| ▸ | MAOB | P27338 | 3/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | CCR6 | P51684 | 1/20 | 0.47 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL10426109 | 1.00 | BCHE (0.54) | BCHEACHEMAOBHSP90AA1CCR6 | |
| SCHEMBL10426020 | 0.99 | BCHE (0.55) | BCHEACHEMAOBHSP90AA1CCR6 | |
| SCHEMBL10426021 | 0.99 | BCHE (0.55) | BCHEACHEMAOBHSP90AA1CCR6 | |
| Bromide SCHEMBL10426077 | 0.83 | LMNA (0.50) | KDM4EALDH1A1LMNAMAPT | |
| SCHEMBL10426023 | 0.83 | BCHE (0.59) | BCHEACHEMAOBKDM4EALDH1A1 | |
| Bromide SCHEMBL10426701 | 0.81 | ALDH1A1 (0.55) | MAOBKDM4EALDH1A1LMNAMAPT | |
| SCHEMBL10425884 | 0.80 | ALDH1A1 (0.56) | MAOBKDM4EALDH1A1LMNAMAPT | |
| Bromide SCHEMBL10425849 | 0.79 | BCHE (0.53) | BCHEACHEMAOBKDM4EALDH1A1 | |
| SCHEMBL5109206 | 0.78 | L3MBTL1 (0.53) | BCHEACHEKDM4EALDH1A1LMNA | |
| SCHEMBL10426725 | 0.78 | BCHE (0.53) | BCHEACHEMAOBKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4906634-A | Novel N-[4-(aminosubstituted)phenyl]methanesulfonamides and their use as cardiovascular agents | SCHERING A.G. (DE) | 1990-03-06 | — | — | US | disclosed |
| EP-0332570-A2 | Novel-N-(4-(Aminosubstituted)phenyl) methanesulfonamides and their use as cardiovascular agents | SCHERING AKTIENGESELLSCHAFT (DE) | 1989-09-13 | — | — | EP | disclosed |