Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | NPY1R | P25929 | 1/20 | 0.37 |
| ▸ | NPY2R | P49146 | 1/20 | 0.37 |
| ▸ | NPY4R | P50391 | 1/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 1/20 | 0.32 |
| ▸ | NOS2 | P35228 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10426697 | 1.00 | NFE2L2 (0.42) | NFE2L2GPR119TDP1TSHRNPY1R | |
| SCHEMBL10426699 | 1.00 | NFE2L2 (0.42) | NFE2L2GPR119TDP1TSHRNPY1R | |
| SCHEMBL10426032 | 0.79 | SMN1; SMN2 (0.44) | GPR119TSHRMAPK1ALDH1A1CYP3A4 | |
| SCHEMBL10426031 | 0.79 | SMN1; SMN2 (0.44) | GPR119TSHRMAPK1ALDH1A1CYP3A4 | |
| SCHEMBL10426030 | 0.79 | SMN1; SMN2 (0.44) | GPR119TSHRMAPK1ALDH1A1CYP3A4 | |
| Hydrochloric Acid SCHEMBL10426025 | 0.78 | SMN1; SMN2 (0.43) | GPR119ALDH1A1 | |
| Hydrochloric Acid SCHEMBL10426026 | 0.78 | SMN1; SMN2 (0.43) | GPR119ALDH1A1 | |
| Hydrochloric Acid SCHEMBL10426028 | 0.78 | SMN1; SMN2 (0.43) | GPR119ALDH1A1 | |
| SCHEMBL10426790 | 0.77 | NPC1 (0.46) | GPR119TSHRMAPK1ALDH1A1RECQL | |
| SCHEMBL10426061 | 0.77 | NOS3 (0.40) | TDP1OPRM1ALDH1A1NOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4906634-A | Novel N-[4-(aminosubstituted)phenyl]methanesulfonamides and their use as cardiovascular agents | SCHERING A.G. (DE) | 1990-03-06 | — | — | US | disclosed |
| EP-0332570-A2 | Novel-N-(4-(Aminosubstituted)phenyl) methanesulfonamides and their use as cardiovascular agents | SCHERING AKTIENGESELLSCHAFT (DE) | 1989-09-13 | — | — | EP | disclosed |