Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | FDPS | P14324 | 1/20 | 0.42 |
| ▸ | SPHK1 | Q9NYA1 | 3/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | GMNN | O75496 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | THPO | P40225 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL9486583 | 0.96 | LMNA (0.44) | LMNAALDH1A1HSD17B10MEN1KMT2A | |
| Bromide SCHEMBL9488266 | 0.92 | LMNA (0.42) | LMNAALDH1A1HSD17B10MEN1KMT2A | |
| Bromide SCHEMBL7774753 | 0.92 | LMNA (0.42) | LMNAALDH1A1HSD17B10MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL9487806 | 0.92 | LMNA (0.44) | LMNAALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL16794807 | 0.90 | LMNA (0.43) | LMNAALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL8546915 | 0.90 | LMNA (0.43) | LMNAALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL28464782 | 0.90 | LMNA (0.43) | LMNAALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL28459947 | 0.90 | LMNA (0.43) | LMNAALDH1A1HSD17B10MEN1KMT2A | |
| Bromide SCHEMBL2348951 | 0.90 | FDPS (0.44) | LMNATSHRFDPSSPHK1CYP2D6 | |
| Bromide SCHEMBL29191531 | 0.90 | FDPS (0.44) | LMNATSHRFDPSSPHK1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2282351-A | — | — | None | — | — | JP | disclosed |
| JP-H02282351-A | AMPHIPHATIC QUATERNARY AMMONIUM SALT DERIVATIVE HAVING TERMINAL HYDROXYL GROUP | AGENCY OF IND SCIENCE & TECHNOL | 1990-11-19 | — | — | JP | disclosed |