Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Phenylalanine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 4/20 | 0.43 |
| ▸ | ANPEP | P15144 | 1/20 | 0.42 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.42 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.42 |
| ▸ | ALPI | P09923 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | XIAP | P98170 | 1/20 | 0.41 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.41 |
| ▸ | CTSC | P53634 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.37 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.37 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.34 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.34 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dl-Phenylalanine SCHEMBL28426336 | 1.00 | REN (0.43) | RENANPEPRNPEPDNPEPALPI | |
| Dl-Phenylalanine SCHEMBL10428635 | 1.00 | REN (0.43) | RENANPEPRNPEPDNPEPALPI | |
| Phenylalanine SCHEMBL6139176 | 0.94 | ANPEP (0.46) | RENANPEPRNPEPDNPEPALPI | |
| Dl-Phenylalanine SCHEMBL29048350 | 0.94 | ANPEP (0.46) | RENANPEPRNPEPDNPEPALPI | |
| Dl-Phenylalanine SCHEMBL28971371 | 0.92 | ANPEP (0.45) | RENANPEPRNPEPDNPEPALPI | |
| Dl-Phenylalanine SCHEMBL10379632 | 0.92 | ANPEP (0.43) | RENANPEPRNPEPDNPEPALPI | |
| Dl-Phenylalanine SCHEMBL27660741 | 0.91 | SLC7A5 (0.49) | RENANPEPRNPEPDNPEPALPI | |
| Tyrosine SCHEMBL28971385 | 0.91 | SLC7A5 (0.41) | RENSLC7A5SLC6A2 | |
| Phenylalanine SCHEMBL7612821 | 0.90 | SLC7A5 (0.50) | RENANPEPRNPEPDNPEPALPI | |
| Dl-Phenylalanine SCHEMBL29050658 | 0.90 | SLC7A5 (0.50) | RENANPEPRNPEPDNPEPALPI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0368920-A1 | LECTINES FIXING BETA-D-GALACTOSIDE. | IDEON CORP (US) | 1990-05-23 | — | — | EP | claimed |
| WO-1989000581-A1 | LECTINES FIXING BETA-D-GALACTOSIDE | IDEON CORPORATION (US) | 1989-01-26 | — | — | WO | claimed |
| EP-0368920-A1 | LECTINES FIXING BETA-D-GALACTOSIDE. | IDEON CORP (US) | 1990-05-23 | — | — | EP | disclosed |
| WO-1989000581-A1 | LECTINES FIXING BETA-D-GALACTOSIDE | IDEON CORPORATION (US) | 1989-01-26 | — | — | WO | disclosed |