Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | KCNH3 | Q9ULD8 | 3/20 | 0.47 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.40 |
| ▸ | KDM6B | O15054 | 1/20 | 0.40 |
| ▸ | KDM4A | O75164 | 1/20 | 0.40 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.40 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11098575 | 0.87 | ALDH1A1 (0.54) | ALDH1A1KDM4EHPGDKCNH3GPR55 | |
| Hydrochloric Acid SCHEMBL10508061 | 0.86 | ALDH1A1 (0.53) | ALDH1A1KDM4EHPGDKCNH3GPR55 | |
| SCHEMBL8249024 | 0.84 | CA12 (0.49) | ALDH1A1KDM4EHPGDRPS6KB1KDM4C | |
| SCHEMBL16489567 | 0.84 | KDM4E (0.54) | ALDH1A1KDM4EHPGDRPS6KB1APP | |
| SCHEMBL16489564 | 0.83 | KDM4C (0.56) | ALDH1A1KDM4EHPGDKCNH3HTT | |
| SCHEMBL4718906 | 0.83 | ASPH (0.45) | KDM4EAPP | |
| SCHEMBL16489574 | 0.83 | MEN1 (0.47) | ALDH1A1KDM4EHPGDRPS6KB1 | |
| SCHEMBL7012861 | 0.79 | RPS6KB1 (0.55) | ALDH1A1KDM4EHPGDL3MBTL1RPS6KB1 | |
| SCHEMBL9134263 | 0.76 | HDAC1 (0.49) | ALDH1A1KDM4EKCNH3APP | |
| SCHEMBL16489576 | 0.75 | MAP4K4 (0.47) | ALDH1A1KDM4EHPGDKCNH3L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151824-B1 | N-(4-PIPERIDINYL) BICYCLIC CONDENSED 2-IMIDAZOLAMINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-04-04 | — | — | EP | disclosed |
| EP-0099139-B1 | NOVEL N-(BICYCLIC HETEROCYCLYL)-4-PIPERIDINAMINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1987-02-11 | — | — | EP | disclosed |
| EP-0151824-A2 | N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-08-21 | — | — | EP | disclosed |
| EP-0151826-A1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-08-21 | — | — | EP | disclosed |