Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | XDH | P47989 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.34 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.34 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10429364 | 0.86 | NOTUM (0.33) | NOTUMALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL10429331 | 0.85 | NOTUM (0.43) | NOTUMALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL10429361 | 0.84 | MAOB (0.36) | NPC1RAB9AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL10429298 | 0.84 | NOTUM (0.39) | ADORA3NOTUMHTR7GRIN2DGRIN3B | |
| SCHEMBL10429312 | 0.84 | NOTUM (0.39) | ADORA3NOTUMHTR7 | |
| SCHEMBL10429305 | 0.84 | NOTUM (0.42) | NOTUMALDH1A1SMN1; SMN2MAPTMEN1 | |
| SCHEMBL2121780 | 0.83 | NPSR1 (0.40) | NPC1RAB9AALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL7166444 | 0.81 | NOTUM (0.42) | NOTUMRAB9AALDH1A1SMN1; SMN2XDH | |
| SCHEMBL10429323 | 0.81 | MAOB (0.40) | NOTUMXDH | |
| SCHEMBL17968384 | 0.79 | TSHR (0.46) | ADORA3NPC1RAB9AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4920119-A | XANTHINE OXIDASE INHIBITORS; CONTROL OR PREVENTION OF GOUT OR ISCHEMIA | HOFFMANN-LA ROCHE INC. (US) | 1990-04-24 | — | — | US | disclosed |
| EP-0274654-A2 | 1,2,3-Triazin-4(3H)-one derivatives, process for their preparation and medicaments containing them | F. HOFFMANN-LA ROCHE AG (CH) | 1988-07-20 | — | — | EP | disclosed |