Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 1/20 | 0.50 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAT2A | P31153 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | TNKS | O95271 | 2/20 | 0.40 |
| ▸ | PARP1 | P09874 | 2/20 | 0.40 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.38 |
| ▸ | SCN4A | P35499 | 1/20 | 0.38 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10429297 | 0.81 | NPSR1 (0.47) | PDE3BPDE3AALDH1A1HPGDKDM4E | |
| SCHEMBL10429352 | 0.80 | GSTP1 (0.45) | ALDH1A1NPC1MEN1KMT2ALMNA | |
| SCHEMBL10429333 | 0.80 | PDE4A (0.43) | ALDH1A1HPGDKDM4ENPC1TNKS | |
| SCHEMBL10429349 | 0.80 | PDE4A (0.43) | DYRK1ATNKSTNKS2 | |
| SCHEMBL10429318 | 0.78 | PDE4A (0.40) | PDE3BPDE3AALDH1A1HPGDTNKS | |
| SCHEMBL10429367 | 0.73 | HPGD (0.47) | ALDH1A1HPGDKDM4ENPC1GSK3A | |
| SCHEMBL2887372 | 0.73 | KDM4E (0.54) | PDE3BPDE3AALDH1A1HPGDKDM4E | |
| SCHEMBL2885503 | 0.69 | CCNE2 (0.56) | PDE3BPDE3AALDH1A1KDM4ENPC1 | |
| SCHEMBL10429345 | 0.69 | TDO2 (0.51) | ALDH1A1LMNAKCNA5NOTUMXDH | |
| SCHEMBL15144399 | 0.69 | PDE3B (0.51) | PDE3BPDE3AALDH1A1HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0274654-A2 | 1,2,3-Triazin-4(3H)-one derivatives, process for their preparation and medicaments containing them | F. HOFFMANN-LA ROCHE AG (CH) | 1988-07-20 | — | — | EP | claimed |
| US-4920119-A | XANTHINE OXIDASE INHIBITORS; CONTROL OR PREVENTION OF GOUT OR ISCHEMIA | HOFFMANN-LA ROCHE INC. (US) | 1990-04-24 | — | — | US | disclosed |
| EP-0274654-A2 | 1,2,3-Triazin-4(3H)-one derivatives, process for their preparation and medicaments containing them | F. HOFFMANN-LA ROCHE AG (CH) | 1988-07-20 | — | — | EP | disclosed |