Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 12/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9548068 | 0.85 | PTGS2 (0.48) | PTGS2PTGS1HSD17B10MEN1KMT2A | |
| SCHEMBL9548044 | 0.81 | PTGS2 (0.72) | PTGS2PTGS1HSD17B10MEN1KMT2A | |
| SCHEMBL10430827 | 0.79 | PTGS2 (0.42) | PTGS2PTGS1HSD17B10MEN1KMT2A | |
| SCHEMBL9547975 | 0.71 | PTGS2 (0.66) | PTGS2PTGS1HSD17B10MEN1KMT2A | |
| SCHEMBL8797198 | 0.70 | PTGS2 (0.63) | PTGS2PTGS1 | |
| SCHEMBL8297008 | 0.68 | PTGS2 (0.65) | PTGS2PTGS1 | |
| SCHEMBL6501123 | 0.66 | PTGS2 (0.67) | PTGS2PTGS1KDM4EMAPK14 | |
| SCHEMBL17899432 | 0.65 | HPGD (0.49) | PTGS2PTGS1HSD17B10MEN1KMT2A | |
| SCHEMBL15269269 | 0.65 | HPGD (0.49) | PTGS2PTGS1HSD17B10MEN1KMT2A | |
| SCHEMBL9548039 | 0.65 | PTGS2 (0.78) | PTGS2PTGS1HSD17B10MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0377457-A1 | Thiazole compounds, processes for the preparation thereof, and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1990-07-11 | — | — | EP | disclosed |