Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 2/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.36 |
| ▸ | DAO | P14920 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.35 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19393060 | 1.00 | LTA4H (0.45) | LTA4HCA2DRD2AKR1B1CYP19A1 | |
| SCHEMBL1042716 | 1.00 | LTA4H (0.45) | LTA4HCA2DRD2AKR1B1CYP19A1 | |
| SCHEMBL8344689 | 0.79 | CA2 (0.49) | CA2AKR1B1CYP19A1FFAR1MEN1 | |
| SCHEMBL1043313 | 0.79 | AKR1B1 (0.40) | LTA4HAKR1B1 | |
| SCHEMBL1043068 | 0.78 | LTA4H (0.45) | LTA4HCA2DRD2AKR1B1CYP19A1 | |
| SCHEMBL30438928 | 0.78 | CHRNB4 (0.52) | DRD2 | |
| SCHEMBL16656033 | 0.78 | PBRM1 (0.50) | CA2AKR1B1CYP19A1FFAR1HCRTR2 | |
| SCHEMBL1044542 | 0.78 | PBRM1 (0.50) | CA2AKR1B1CYP19A1FFAR1HCRTR2 | |
| SCHEMBL1877576 | 0.78 | CA2 (0.48) | CA2DRD2AKR1B1CYP19A1FFAR1 | |
| SCHEMBL1879365 | 0.78 | CHRNB4 (0.52) | DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2271635-A1 | MODULATORS OF DOPAMINE NEUROTRANSMISSION | NSAB, Filial af NeuroSearch Sweden AB, Sverige (DK) | 2011-01-12 | — | — | EP | disclosed |
| WO-2009133109-A1 | MODULATORS OF DOPAMINE NEUROTRANSMISSION | NSAB, FILIAL AF NEUROSEARCH SWEDEN AB, SVERIGE (DK) | 2009-11-05 | — | — | WO | disclosed |