Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | REN | P00797 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10431137 | 0.79 | ACE (0.39) | ACEREN | |
| SCHEMBL11014616 | 0.78 | F2 (0.35) | ACEREN | |
| SCHEMBL10431448 | 0.78 | ACE (0.33) | ACE | |
| SCHEMBL16359592 | 0.75 | ACE (0.39) | ACE | |
| SCHEMBL31020879 | 0.73 | ACE (0.38) | ACEREN | |
| SCHEMBL30343746 | 0.70 | ERAP2 (0.34) | — | |
| SCHEMBL30873804 | 0.70 | FCER2 (0.41) | REN | |
| SCHEMBL27756043 | 0.69 | PARP1 (0.33) | — | |
| SCHEMBL29384685 | 0.69 | ECE1 (0.37) | ACEREN | |
| SCHEMBL29517172 | 0.69 | ERAP2 (0.35) | ACEREN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0400290-A1 | 5-Amino-4-hydroxyvalerianic acid derivatives useful as intermediates in the preparation of renin inhibitors | CIBA-GEIGY AG (CH) | 1990-12-05 | — | — | EP | disclosed |
| EP-0143746-A2 | 5-Amino 4-hydroxy-valeryl-substituted derivatives | CIBA-GEIGY AG (CH) | 1985-06-05 | — | — | EP | disclosed |