Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 2/20 | 0.45 |
| ▸ | METAP2 | P50579 | 3/20 | 0.45 |
| ▸ | METAP1 | P53582 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SLC1A3 | P43003 | 3/20 | 0.37 |
| ▸ | SLC1A2 | P43004 | 3/20 | 0.37 |
| ▸ | SLC1A1 | P43005 | 3/20 | 0.37 |
| ▸ | GABRP | O00591 | 2/20 | 0.37 |
| ▸ | GABRD | O14764 | 2/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.37 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.37 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.37 |
| ▸ | GABRE | P78334 | 2/20 | 0.37 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3293610 | 0.87 | REN (0.45) | RENMETAP2METAP1 | |
| SCHEMBL7353974 | 0.84 | LMNA (0.43) | METAP2METAP1LMNA | |
| SCHEMBL272993 | 0.83 | REN (0.47) | RENMETAP2METAP1SLC1A3SLC1A2 | |
| SCHEMBL21690082 | 0.83 | REN (0.47) | RENMETAP2METAP1SLC1A3SLC1A2 | |
| SCHEMBL7151431 | 0.83 | REN (0.47) | RENMETAP2METAP1SLC1A3SLC1A2 | |
| SCHEMBL287986 | 0.81 | ANPEP (0.47) | LMNASLC1A3SLC1A2SLC1A1GABRP | |
| SCHEMBL4404266 | 0.81 | ANPEP (0.47) | LMNASLC1A3SLC1A2SLC1A1GABRP | |
| SCHEMBL7274772 | 0.80 | REN (0.44) | RENMETAP2METAP1GABRPGABRD | |
| SCHEMBL10727830 | 0.79 | METAP1 (0.49) | RENMETAP2METAP1CYP1A2 | |
| SCHEMBL10520380 | 0.79 | REN (0.43) | RENMETAP2METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0369141-A1 | Aspartic protease inhibitors for the treatment of diseases caused by retroviruses | MERCK PATENT GmbH (DE) | 1990-05-23 | — | — | EP | disclosed |