Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DBH | P09172 | 18/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.60 |
| ▸ | BLM | P54132 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9371273 | 0.72 | DBH (0.60) | DBHALDH1A1POLBCYP1A2CYP3A4 | |
| SCHEMBL9375216 | 0.69 | DBH (0.56) | DBHALDH1A1POLBCYP1A2CYP3A4 | |
| SCHEMBL10448529 | 0.69 | DBH (0.47) | DBHALDH1A1POLBCYP1A2CYP3A4 | |
| SCHEMBL10621834 | 0.68 | DBH (1.00) | DBHALDH1A1POLBCYP1A2CYP3A4 | |
| SCHEMBL11565100 | 0.67 | — | — | |
| SCHEMBL28039038 | 0.67 | HDAC1 (0.38) | ALDH1A1POLBCYP1A2CYP3A4ATM | |
| SCHEMBL11565383 | 0.66 | — | — | |
| SCHEMBL9369333 | 0.66 | DBH (0.56) | DBHALDH1A1POLBCYP1A2CYP3A4 | |
| SCHEMBL10624621 | 0.65 | DBH (1.00) | DBHALDH1A1POLBCYP1A2CYP3A4 | |
| SCHEMBL10621922 | 0.65 | DBH (1.00) | DBHALDH1A1POLBCYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0371732-A1 | Dopamine-beta-hydroxylase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1990-06-06 | — | — | EP | disclosed |