Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DBH | P09172 | 9/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | LPO | P22079 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11079680 | 0.72 | DBH (1.00) | DBHALDH1A1POLBKMT2ACYP1A2 | |
| SCHEMBL11565383 | 0.68 | — | — | |
| SCHEMBL9369333 | 0.67 | DBH (0.56) | DBHALDH1A1POLBCYP1A2CYP3A4 | |
| SCHEMBL10433726 | 0.66 | KMT2A (0.56) | DBHALDH1A1POLBKMT2ACYP1A2 | |
| SCHEMBL10621217 | 0.66 | DBH (0.66) | DBHALDH1A1POLBCYP1A2CYP3A4 | |
| SCHEMBL11565100 | 0.65 | — | — | |
| SCHEMBL10103709 | 0.65 | MEN1 (0.44) | ALDH1A1POLBKMT2ACYP3A4TSHR | |
| SCHEMBL7531600 | 0.65 | KMT2A (0.50) | DBHALDH1A1POLBKMT2ACYP1A2 | |
| SCHEMBL10433727 | 0.64 | POLB (0.63) | DBHALDH1A1POLBKMT2ACYP1A2 | |
| SCHEMBL9585052 | 0.64 | POLB (0.53) | DBHALDH1A1POLBKMT2AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0244803-B1 | Novel dopamine beta hydroxylase inhibitors | MERRELL DOW PHARMA (US) | 1994-10-26 | — | — | EP | disclosed |
| US-4810800-A | HYPOTENSIVE AGENTS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-03-07 | — | — | US | disclosed |
| EP-0244803-A2 | Novel dopamine beta hydroxylase inhibitors | MERRELL DOW PHARMACEUTICALS INC. (US) | 1987-11-11 | — | — | EP | disclosed |