Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.86 |
| ▸ | LMNA | P02545 | 4/20 | 0.86 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.86 |
| ▸ | MAPT | P10636 | 3/20 | 0.86 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.86 |
| ▸ | ATM | Q13315 | 1/20 | 0.86 |
| ▸ | NPC1 | O15118 | 2/20 | 0.65 |
| ▸ | RAB9A | P51151 | 2/20 | 0.65 |
| ▸ | TP53 | P04637 | 1/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.61 |
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 5/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.59 |
| ▸ | FOS | P01100 | 4/20 | 0.55 |
| ▸ | JUN | P05412 | 4/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.55 |
| ▸ | NFKB2 | Q00653 | 4/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10434142 | 0.85 | ALDH1A1 (0.80) | ALDH1A1LMNASMN1; SMN2MAPTMAPK1 | |
| SCHEMBL10433999 | 0.84 | ALDH1A1 (0.83) | ALDH1A1LMNASMN1; SMN2MAPTMAPK1 | |
| SCHEMBL10377448 | 0.84 | ALDH1A1 (0.78) | ALDH1A1LMNASMN1; SMN2MAPTMAPK1 | |
| SCHEMBL5014336 | 0.84 | FOS (0.60) | ALDH1A1LMNASMN1; SMN2MAPTMAPK1 | |
| SCHEMBL31115747 | 0.81 | ALDH1A1 (0.56) | ALDH1A1LMNASMN1; SMN2MAPTMAPK1 | |
| SCHEMBL1965857 | 0.81 | ALDH1A1 (0.78) | ALDH1A1LMNASMN1; SMN2MAPTMAPK1 | |
| SCHEMBL3572484 | 0.81 | ALDH1A1 (0.78) | ALDH1A1LMNASMN1; SMN2MAPTMAPK1 | |
| SCHEMBL28509330 | 0.81 | MDM2 (0.60) | ALDH1A1LMNASMN1; SMN2MAPTMAPK1 | |
| SCHEMBL12929551 | 0.81 | FOS (0.66) | ALDH1A1LMNASMN1; SMN2MAPTMAPK1 | |
| SCHEMBL8946584 | 0.80 | ALDH1A1 (0.76) | ALDH1A1LMNASMN1; SMN2MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0367895-A1 | Pyrimidinyl-substituted hydroxyacids, lactones and esters and pharmaceutical compositions containing them | SANDOZ AG (CH) | 1990-05-16 | — | — | EP | disclosed |
| WO-1990003973-A1 | PYRIMIDINYL-SUBSTITUTED HYDROXYACIDS, LACTONES AND ESTERS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SANDOZ AG (CH) | 1990-04-19 | — | — | WO | disclosed |