SCHEMBL10434871

SCHEMBL10434871

CN1C(C)(C)CC(NNC(=O)CCC(N)=O)CC1(C)C

nearest known ligand 0.31

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.30
KDM5C P41229 1/20 0.30
EGLN1 Q9GZT9 1/20 0.30
PHF8 Q9UPP1 1/20 0.30
KDM2A Q9Y2K7 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10434650 0.80 GAA (0.44) KDM4E
SCHEMBL9823089 0.79 EZH2 (0.32)
SCHEMBL7914274 0.72 GAA (0.43) KDM4E
SCHEMBL9300620 0.72 HTT (0.41) KDM4EKDM5CPHF8KDM2A
SCHEMBL11046524 0.70 MAOB (0.39) KDM4E
SCHEMBL13298035 0.68 SMN1; SMN2 (0.47)
SCHEMBL10444901 0.68 KDM4E (0.37) KDM4E
SCHEMBL8333479 0.68 POLB (0.40) KDM4EKDM5CPHF8KDM2A
SCHEMBL13871636 0.68 TSHR (0.41)
SCHEMBL28889135 0.68 HDAC4 (0.39) KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0366057-A2 Light stabilizing flame retardants ATOCHEM NORTH AMERICA, INC. (a Pennsylvania corp.) (US) 1990-05-02 EP disclosed
EP-0303987-A2 Polymer bound hindered amine light stabilizers ATOCHEM NORTH AMERICA, INC. (US) 1989-02-22 EP disclosed
EP-0303282-A2 Cyclic anhydride derivatives of hydrazide functionalized hindered amine light stabilizers ATOCHEM NORTH AMERICA, INC. (US) 1989-02-15 EP disclosed