SCHEMBL10436239

SCHEMBL10436239

COc1ccc(OC(=O)c2ccccc2)cc1OC

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 11/20 0.60
MEN1 O00255 4/20 0.60
MAPT P10636 4/20 0.60
TDP1 Q9NUW8 3/20 0.60
L3MBTL1 Q9Y468 2/20 0.56
CYP3A4 P08684 1/20 0.56
PARP10 Q53GL7 1/20 0.56
ALDH1A1 P00352 3/20 0.54
KDM4E B2RXH2 1/20 0.54
GAA P10253 1/20 0.54
MAPK1 P28482 1/20 0.54
PKM P14618 1/20 0.53
NPC1 O15118 2/20 0.52
RAB9A P51151 2/20 0.52
CA12 O43570 1/20 0.51
CA1 P00915 1/20 0.51
CA2 P00918 1/20 0.51
CA4 P22748 1/20 0.51
CA6 P23280 1/20 0.51
CA7 P43166 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26659601 0.89 KMT2A (0.66) KMT2AMEN1MAPTTDP1L3MBTL1
SCHEMBL14029066 0.89 KMT2A (0.57) KMT2AMEN1MAPTTDP1L3MBTL1
SCHEMBL28518633 0.88 KMT2A (0.69) KMT2AMEN1MAPTCYP3A4ALDH1A1
SCHEMBL4581548 0.87 CYP1A2 (0.63) KMT2AMEN1MAPTTDP1L3MBTL1
SCHEMBL14767680 0.87 KMT2A (0.57) KMT2AMEN1MAPTTDP1L3MBTL1
SCHEMBL10910755 0.87 KMT2A (0.57) KMT2AMEN1MAPTTDP1L3MBTL1
SCHEMBL27914465 0.86 PARP10 (0.56) KMT2AMEN1MAPTTDP1L3MBTL1
SCHEMBL17301265 0.86 KMT2A (0.59) KMT2AMEN1MAPTTDP1L3MBTL1
SCHEMBL17933739 0.86 MAPT (0.70) KMT2AMEN1MAPTCYP3A4ALDH1A1
SCHEMBL10909497 0.86 SMPD1 (0.60) KMT2AMEN1MAPTTDP1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0360701-A1 Antifungal compounds containing amides and phenyl groups RHONE-POULENC AGROCHIMIE (FR) 1990-03-28 EP disclosed