Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTAFR known ✓ | P25105 | 1/20 | 0.37 |
| ▸ | CHRM2 known ✓ | P08172 | 2/20 | 0.34 |
| ▸ | CHRM1 known ✓ | P11229 | 2/20 | 0.34 |
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.34 |
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 0.34 |
| ▸ | SLC6A3 known ✓ | Q01959 | 2/20 | 0.34 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | CASP2 | P42575 | 1/20 | 0.36 |
| ▸ | RAD52 | P43351 | 3/20 | 0.35 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.35 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9716335 | 0.85 | MEN1 (0.40) | KMT2ASMN1; SMN2MEN1MAPTMAPK1 | |
| Hydrochloric Acid SCHEMBL9716328 | 0.83 | KMT2A (0.33) | PTAFRKMT2ASMN1; SMN2MEN1MAPT | |
| SCHEMBL9716227 | 0.82 | MEN1 (0.42) | KMT2ASMN1; SMN2MEN1MAPTMAPK1 | |
| Hydrochloric Acid SCHEMBL9716276 | 0.81 | PRKD3 (0.47) | PTAFRKMT2ASMN1; SMN2MEN1MAPK1 | |
| SCHEMBL9716310 | 0.80 | TLR2 (0.33) | PLA2G4B | |
| Hydrochloric Acid SCHEMBL9716239 | 0.80 | PRKD3 (0.46) | PTAFRKMT2ASMN1; SMN2MEN1MAPK1 | |
| SCHEMBL9716244 | 0.79 | USP2 (0.38) | KMT2AMEN1MAPTHTTTHRB | |
| Hydrochloric Acid SCHEMBL9716349 | 0.78 | KMT2A (0.36) | PTAFRKMT2ASMN1; SMN2MEN1MAPT | |
| Hydrochloric Acid SCHEMBL9716388 | 0.78 | KMT2A (0.36) | PTAFRKMT2ASMN1; SMN2MEN1MAPT | |
| SCHEMBL9716423 | 0.78 | PLA2G2A (0.37) | HTTLMNAPLA2G1BPLA2G4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0378763-A1 | Lipids, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1990-07-25 | — | — | EP | disclosed |