Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 18/20 | 0.49 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.49 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.49 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.49 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.49 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.49 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.49 |
| ▸ | BACE1 | P56817 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL10444549 | 0.89 | REN (0.57) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL10443609 | 0.86 | REN (0.61) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL10443607 | 0.86 | REN (0.61) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL10444511 | 0.77 | REN (0.71) | REN | |
| SCHEMBL10444086 | 0.77 | REN (0.71) | REN | |
| Trifluoroacetic Acid SCHEMBL10444546 | 0.76 | PSEN1 (0.53) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7269492 | 0.75 | REN (0.57) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7269499 | 0.75 | REN (0.57) | RENPSEN1PSEN2APH1BNCSTN | |
| Water SCHEMBL10443791 | 0.75 | REN (0.41) | REN | |
| SCHEMBL7431995 | 0.74 | REN (0.56) | RENPSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0350163-A2 | Renin inhibitory peptides | BEECHAM GROUP PLC (GB) | 1990-01-10 | — | — | EP | disclosed |