Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 18/20 | 0.57 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.55 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.55 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.55 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.55 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.55 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.55 |
| ▸ | CTSD | P07339 | 1/20 | 0.48 |
| ▸ | PGA5 | P0DJD9 | 1/20 | 0.48 |
| ▸ | CTSE | P14091 | 1/20 | 0.48 |
| ▸ | PGC | P20142 | 1/20 | 0.48 |
| ▸ | BACE1 | P56817 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7269499 | 1.00 | REN (0.57) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9555781 | 0.87 | REN (0.52) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9725895 | 0.86 | REN (0.61) | REN | |
| SCHEMBL9725900 | 0.86 | REN (0.61) | REN | |
| SCHEMBL7268380 | 0.86 | PSEN1 (0.46) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7268385 | 0.86 | PSEN1 (0.46) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7321258 | 0.86 | PSEN1 (0.46) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7300500 | 0.85 | REN (0.61) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7300506 | 0.85 | REN (0.61) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9740289 | 0.82 | REN (0.57) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0376040-A2 | N-phosphinyl di-and tripeptides as renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1990-07-04 | — | — | EP | disclosed |