Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A known ✓ | Q03164 | 5/20 | 0.43 |
| ▸ | MEN1 known ✓ | O00255 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.43 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.40 |
| ▸ | METAP1 | P53582 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | CRHBP | P24387 | 2/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.36 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL10445801 | 1.00 | MAPT (0.46) | MAPTRAB9ANPC1SMN1; SMN2HPGD | |
| Fumaric Acid SCHEMBL10445797 | 1.00 | MAPT (0.46) | MAPTRAB9ANPC1SMN1; SMN2HPGD | |
| Fumaric Acid SCHEMBL9249668 | 0.77 | HSD17B3 (0.47) | MAPTRAB9ANPC1SMN1; SMN2HPGD | |
| Fumaric Acid SCHEMBL9249683 | 0.77 | HSD17B3 (0.47) | MAPTRAB9ANPC1SMN1; SMN2HPGD | |
| SCHEMBL1890697 | 0.72 | CYP1A2 (0.44) | MAPTRAB9ANPC1SMN1; SMN2HPGD | |
| SCHEMBL1890698 | 0.72 | CYP1A2 (0.44) | MAPTRAB9ANPC1SMN1; SMN2HPGD | |
| SCHEMBL2261719 | 0.71 | CYP1A2 (0.41) | MAPTRAB9ANPC1SMN1; SMN2HPGD | |
| SCHEMBL2258288 | 0.71 | CYP1A2 (0.41) | MAPTRAB9ANPC1SMN1; SMN2HPGD | |
| SCHEMBL28154529 | 0.71 | CYP1A2 (0.49) | MAPTRAB9ANPC1SMN1; SMN2HPGD | |
| SCHEMBL28154528 | 0.71 | CYP1A2 (0.49) | MAPTRAB9ANPC1SMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0378207-A1 | Cyclic amine compounds and their use | Takeda Chemical Industries, Ltd. (JP) | 1990-07-18 | — | — | EP | disclosed |