Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.44 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.48 |
| ▸ | UTS2R | Q9UKP6 | 10/20 | 0.47 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL10101 | 0.89 | SLC6A9 (0.47) | SLC6A9UTS2RCACNA2D1SLC6A4HRH3 | |
| Oxalic Acid SCHEMBL3485 | 0.89 | SLC6A9 (0.47) | SLC6A9CACNA2D1SLC6A4HRH3 | |
| Oxalic Acid SCHEMBL10359897 | 0.86 | SLC6A4 (0.62) | SLC6A9UTS2RCACNA2D1SLC6A4HRH3 | |
| Oxalic Acid SCHEMBL3799 | 0.84 | SLC6A4 (0.58) | CACNA2D1SLC6A4 | |
| Oxalic Acid SCHEMBL7307609 | 0.82 | SLC6A9 (0.69) | SLC6A9UTS2RSLC6A4HRH3 | |
| SCHEMBL19553106 | 0.80 | CACNA2D1 (0.42) | SLC6A9CACNA2D1 | |
| SCHEMBL19553104 | 0.80 | CACNA2D1 (0.42) | SLC6A9CACNA2D1 | |
| Oxalic Acid SCHEMBL3699 | 0.79 | KMT2A (0.52) | CACNA2D1SLC6A4 | |
| SCHEMBL19553331 | 0.78 | SLC7A5 (0.41) | SLC6A9CACNA2D1 | |
| SCHEMBL19553332 | 0.78 | SLC7A5 (0.41) | SLC6A9CACNA2D1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5023269-A | 3-aryloxy-3-substituted propanamines | ELI LILLY AND COMPANY (US) | 1991-06-11 | — | — | US | disclosed |
| EP-0273658-B1 | 3-ARYLOXY-3-SUBSTITUTED PROPANAMINES | ELI LILLY AND COMPANY (US) | 1990-10-31 | — | — | EP | disclosed |
| US-4956388-A | ANTIDEPRESSANTS, ANTIANXIETY, TREATMENT OF OBESITY, ADDICTION TO SMOKING AND ALCOHOL | ELI LILLY AND COMPANY (US) | 1990-09-11 | — | — | US | disclosed |
| EP-0273658-A1 | 3-Aryloxy-3-substituted propanamines | ELI LILLY AND COMPANY (US) | 1988-07-06 | — | — | EP | disclosed |