Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 2/20 | 0.44 |
| ▸ | SLC6A9 | P48067 | 4/20 | 0.47 |
| ▸ | CACNA2D1 | P54289 | 4/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.44 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.42 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL10101 | 0.91 | SLC6A9 (0.47) | SLC6A9CACNA2D1SLC6A4HRH3SLC7A5 | |
| Oxalic Acid SCHEMBL10450 | 0.89 | SLC6A9 (0.48) | SLC6A9CACNA2D1SLC6A4HRH3 | |
| Oxalic Acid SCHEMBL10359897 | 0.87 | SLC6A4 (0.62) | SLC6A9CACNA2D1SLC6A4HRH3SLC7A5 | |
| Oxalic Acid SCHEMBL10154 | 0.83 | CACNA2D1 (0.58) | CACNA2D1SLC6A4 | |
| Oxalic Acid SCHEMBL5142654 | 0.81 | SLC6A9 (0.68) | SLC6A9SLC6A4HRH3 | |
| SCHEMBL19553331 | 0.79 | SLC7A5 (0.41) | SLC6A9CACNA2D1TRPM8SLC7A5 | |
| SCHEMBL19553332 | 0.79 | SLC7A5 (0.41) | SLC6A9CACNA2D1TRPM8SLC7A5 | |
| SCHEMBL2600190 | 0.79 | CACNA2D1 (0.55) | CACNA2D1SLC6A4HRH3SLC7A5 | |
| SCHEMBL7439700 | 0.79 | SLC6A4 (0.67) | SLC6A9CACNA2D1SLC6A4HRH3SLC7A5 | |
| SCHEMBL13476290 | 0.79 | CACNA2D1 (0.55) | CACNA2D1SLC6A4HRH3SLC7A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5023269-A | 3-aryloxy-3-substituted propanamines | ELI LILLY AND COMPANY (US) | 1991-06-11 | — | — | US | disclosed |
| EP-0273658-B1 | 3-ARYLOXY-3-SUBSTITUTED PROPANAMINES | ELI LILLY AND COMPANY (US) | 1990-10-31 | — | — | EP | disclosed |
| US-4956388-A | ANTIDEPRESSANTS, ANTIANXIETY, TREATMENT OF OBESITY, ADDICTION TO SMOKING AND ALCOHOL | ELI LILLY AND COMPANY (US) | 1990-09-11 | — | — | US | disclosed |
| EP-0273658-A1 | 3-Aryloxy-3-substituted propanamines | ELI LILLY AND COMPANY (US) | 1988-07-06 | — | — | EP | disclosed |