Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 20/20 | 1.00 |
| ▸ | MMP3 | P08254 | 2/20 | 0.76 |
| ▸ | MMP9 | P14780 | 2/20 | 0.76 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.76 |
| ▸ | MMP2 | P08253 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10451722 | 0.91 | MMP1 (0.83) | MMP1MMP3MMP9ADAM17MMP2 | |
| SCHEMBL9650310 | 0.89 | MMP1 (0.86) | MMP1MMP3MMP9ADAM17 | |
| SCHEMBL7284853 | 0.88 | MMP1 (1.00) | MMP1MMP3MMP9ADAM17MMP2 | |
| SCHEMBL7278285 | 0.88 | MMP1 (1.00) | MMP1MMP3MMP9ADAM17MMP2 | |
| SCHEMBL7275835 | 0.88 | MMP1 (1.00) | MMP1MMP3MMP9ADAM17 | |
| SCHEMBL7276467 | 0.88 | MMP1 (1.00) | MMP1MMP3MMP9ADAM17 | |
| SCHEMBL7284842 | 0.88 | MMP1 (1.00) | MMP1MMP3MMP9ADAM17MMP2 | |
| SCHEMBL7278293 | 0.88 | MMP1 (1.00) | MMP1MMP3MMP9ADAM17MMP2 | |
| SCHEMBL10429973 | 0.87 | MMP1 (0.82) | MMP1MMP3MMP9ADAM17MMP2 | |
| SCHEMBL7615635 | 0.87 | MMP1 (1.00) | MMP1MMP3MMP9ADAM17MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0185380-B1 | THIOL BASED COLLAGENASE INHIBITORS | G.D. Searle & Co. (US) | 1990-04-11 | — | — | EP | disclosed |
| US-4681966-A | ANTIARTHRITIC AGENTS | G. D. SEARLE & CO. (US) | 1987-07-21 | — | — | US | disclosed |
| EP-0185380-A2 | Thiol based collagenase inhibitors | G.D. Searle & Co. (US) | 1986-06-25 | — | — | EP | disclosed |
| US-4595700-A | Thiol based collagenase inhibitors | G. D. SEARLE & CO. (US) | 1986-06-17 | — | — | US | disclosed |