Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 2/20 | 0.60 |
| ▸ | DRD1 | P21728 | 2/20 | 0.60 |
| ▸ | DRD3 | P35462 | 2/20 | 0.60 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.60 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.60 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.60 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.60 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.60 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.60 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.60 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.60 |
| ▸ | HRH1 | P35367 | 1/20 | 0.60 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.60 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.60 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.60 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.60 |
| ▸ | ERCC1 | P07992 | 2/20 | 0.49 |
| ▸ | ERCC4 | Q92889 | 2/20 | 0.49 |
| ▸ | DRD2 | P14416 | 4/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10498890 | 0.78 | SLC2A1 (0.60) | KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL7279998 | 0.77 | ADRB2 (0.79) | ADRB2DRD1DRD3ADORA3CHRM1 | |
| SCHEMBL11811440 | 0.76 | ADRB2 (0.73) | ADRB2DRD1DRD3ADORA3CHRM1 | |
| SCHEMBL30088530 | 0.76 | DRD1 (0.71) | ADRB2DRD1DRD3ADORA3CHRM1 | |
| SCHEMBL11806768 | 0.76 | DRD1 (0.71) | ADRB2DRD1DRD3ADORA3CHRM1 | |
| Dopexamine SCHEMBL5605569 | 0.76 | ADRB2 (1.00) | ADRB2DRD1DRD3ADORA3CHRM1 | |
| Dopexamine SCHEMBL122233 | 0.76 | ADRB2 (1.00) | ADRB2DRD1DRD3ADORA3CHRM1 | |
| SCHEMBL19663687 | 0.76 | TAAR1 (0.55) | ADRB2DRD1DRD3SLC6A2ADRA1A | |
| SCHEMBL18546398 | 0.76 | ADRB2 (0.72) | ADRB2DRD1DRD3ADORA3CHRM1 | |
| SCHEMBL7278498 | 0.76 | ADRB2 (1.00) | ADRB2DRD1DRD3ADORA3CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0132267-B1 | AROMATIC AMINES | FISONS plc (GB) | 1989-01-18 | — | — | EP | claimed |
| EP-0118974-B1 | 3,4-DIHYDROXYPHENYL ETHYL AMINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | FISONS plc (GB) | 1989-01-04 | — | — | EP | claimed |
| EP-0132267-A1 | AROMATIC AMINES. | FISONS PLC (GB) | 1985-01-30 | — | — | EP | claimed |
| EP-0118974-A1 | 3,4-Dihydroxyphenyl ethyl amine derivatives and pharmaceutical compositions containing them | FISONS plc (GB) | 1984-09-19 | — | — | EP | claimed |
| WO-1984002904-A1 | AROMATIC AMINES | FISONS PLC (GB) | 1984-08-02 | — | — | WO | claimed |
| US-4914126-A | Aromatic amines | FISONS PLC (GB) | 1990-04-03 | — | — | US | disclosed |
| EP-0132267-B1 | AROMATIC AMINES | FISONS plc (GB) | 1989-01-18 | — | — | EP | disclosed |
| EP-0118974-B1 | 3,4-DIHYDROXYPHENYL ETHYL AMINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | FISONS plc (GB) | 1989-01-04 | — | — | EP | disclosed |
| EP-0132267-A1 | AROMATIC AMINES. | FISONS PLC (GB) | 1985-01-30 | — | — | EP | disclosed |
| EP-0118974-A1 | 3,4-Dihydroxyphenyl ethyl amine derivatives and pharmaceutical compositions containing them | FISONS plc (GB) | 1984-09-19 | — | — | EP | disclosed |
| WO-1984002904-A1 | AROMATIC AMINES | FISONS PLC (GB) | 1984-08-02 | — | — | WO | disclosed |