Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACSL1 | P33121 | 2/20 | 0.43 |
| ▸ | ACSL6 | Q9UKU0 | 2/20 | 0.43 |
| ▸ | MAOB | P27338 | 9/20 | 0.42 |
| ▸ | ALDH2 | P05091 | 2/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.40 |
| ▸ | XDH | P47989 | 5/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10453571 | 0.99 | ACSL1 (0.44) | ACSL1ACSL6MAOBALDH2MAOA | |
| SCHEMBL10454123 | 0.98 | ACSL1 (0.43) | ACSL1ACSL6MAOBALDH2MAOA | |
| SCHEMBL10454211 | 0.96 | ACSL1 (0.44) | ACSL1ACSL6MAOBALDH2HRH3 | |
| SCHEMBL10452909 | 0.95 | ACSL1 (0.45) | ACSL1ACSL6MAOBALDH2HRH3 | |
| SCHEMBL10454213 | 0.94 | ACSL1 (0.44) | ACSL1ACSL6MAOBALDH2HRH3 | |
| SCHEMBL10453751 | 0.91 | XDH (0.42) | ACSL1ACSL6MAOBMAOAHRH3 | |
| SCHEMBL10454166 | 0.90 | XDH (0.43) | ACSL1ACSL6MAOBMAOAHRH3 | |
| SCHEMBL10454198 | 0.90 | XDH (0.45) | ACSL1ACSL6MAOBALDH2HRH3 | |
| SCHEMBL10453752 | 0.89 | XDH (0.42) | ACSL1ACSL6MAOBMAOAHRH3 | |
| SCHEMBL10453668 | 0.89 | MAPT (0.43) | ACSL1ACSL6MAOBALDH2MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4902701-A | Tetrazolyl substituted tricyclic compounds and pharmacological compositions thereof | BURROUGHS WELCOME CO. (US) | 1990-02-20 | — | — | US | disclosed |
| EP-0093381-B1 | TRICYCLIC COMPOUNDS, PREPARATION, USE AND INTERMEDIATES | THE WELLCOME FOUNDATION LIMITED (GB) | 1986-07-23 | — | — | EP | disclosed |
| EP-0093381-A1 | Tricyclic compounds, preparation, use and intermediates | THE WELLCOME FOUNDATION LIMITED (GB) | 1983-11-09 | — | — | EP | disclosed |