Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 3/20 | 0.40 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10453889 | 0.99 | MAPT (0.44) | MAPTTP53RXFP1ALDH1A1KDM4E | |
| SCHEMBL10453670 | 0.98 | MAPT (0.43) | MAPTTP53RXFP1ALDH1A1KDM4E | |
| SCHEMBL10453751 | 0.92 | XDH (0.42) | MAPTALDH1A1KDM4EHPGDNPC1 | |
| SCHEMBL10454198 | 0.91 | XDH (0.45) | ALDH2MAOBXDHACSL1ACSL6 | |
| SCHEMBL10454166 | 0.91 | XDH (0.43) | MAPTALDH1A1KDM4EHPGDNPC1 | |
| SCHEMBL10453752 | 0.90 | XDH (0.42) | MAPTALDH1A1KDM4EHPGDNPC1 | |
| SCHEMBL10454121 | 0.89 | ACSL1 (0.43) | MAOAALDH2MAOBXDHACSL1 | |
| SCHEMBL10452923 | 0.88 | KDM4E (0.56) | MAPTTP53RXFP1ALDH1A1KDM4E | |
| SCHEMBL10453571 | 0.88 | ACSL1 (0.44) | MAOAALDH2MAOBXDHACSL1 | |
| SCHEMBL10453455 | 0.87 | KDM4E (0.39) | MAPTTP53ALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4902701-A | Tetrazolyl substituted tricyclic compounds and pharmacological compositions thereof | BURROUGHS WELCOME CO. (US) | 1990-02-20 | — | — | US | disclosed |
| EP-0093381-B1 | TRICYCLIC COMPOUNDS, PREPARATION, USE AND INTERMEDIATES | THE WELLCOME FOUNDATION LIMITED (GB) | 1986-07-23 | — | — | EP | disclosed |
| EP-0093381-A1 | Tricyclic compounds, preparation, use and intermediates | THE WELLCOME FOUNDATION LIMITED (GB) | 1983-11-09 | — | — | EP | disclosed |