6-Chloronicotinic Acid

6-Chloronicotinic Acid

SCHEMBL104580

O=C(O)c1ccc(Cl)nc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NAPRT Q6XQN6 1/20 1.00
P4HA1 P13674 2/20 0.61
P4HTM Q9NXG6 2/20 0.61
MIF P14174 1/20 0.59
GABRP O00591 1/20 0.57
GABRD O14764 1/20 0.57
GABRA1 P14867 1/20 0.57
GABRB1 P18505 1/20 0.57
GABRG2 P18507 1/20 0.57
GABRB3 P28472 1/20 0.57
GABRA5 P31644 1/20 0.57
GABRA3 P34903 1/20 0.57
GABRA2 P47869 1/20 0.57
GABRB2 P47870 1/20 0.57
GABRA4 P48169 1/20 0.57
GABRE P78334 1/20 0.57
GABRA6 Q16445 1/20 0.57
GABRG1 Q8N1C3 1/20 0.57
GABRG3 Q99928 1/20 0.57
GABRQ Q9UN88 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
6-Chloronicotinic Acid SCHEMBL29524158 1.00 NAPRT (1.00) NAPRTP4HA1P4HTMMIFGABRP
6-Chloronicotinic Acid SCHEMBL523893 0.98 NAPRT (0.96) NAPRTP4HA1P4HTMMIFGABRP
6-Chloronicotinic Acid SCHEMBL10575126 0.98 NAPRT (0.96) NAPRTP4HA1P4HTMMIFGABRP
6-Chloronicotinic Acid SCHEMBL17541528 0.96 NAPRT (0.92) NAPRTP4HA1P4HTMMIFGABRP
6-Chloronicotinic Acid SCHEMBL27649626 0.92 NAPRT (0.85) NAPRTP4HA1P4HTMMIFGABRP
6-Chloronicotinic Acid SCHEMBL3975934 0.87 NAPRT (0.76) NAPRTP4HA1P4HTMMIFGABRP
SCHEMBL7440808 0.84 NAPRT (0.72) NAPRTL3MBTL1DGAT1RAB9ASMN1; SMN2
SCHEMBL17801 0.84 NAPRT (0.72) NAPRTL3MBTL1DGAT1RAB9ASMN1; SMN2
SCHEMBL29760376 0.84 NAPRT (0.72) NAPRTL3MBTL1DGAT1RAB9ASMN1; SMN2
SCHEMBL1109095 0.84 NAPRT (0.71) NAPRTTSHRALOX15KCNQ3KCNQ2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 3399 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4661890-A1 PTP1B/TC-PTP DUAL INHIBITORS AND PROTEIN DEGRADERS Purdue Research Foundation (US) 2025-12-17 EP claimed
CN-119757720-A Method for realizing protein or virus marking 苏州亚科科技股份有限公司 2025-04-04 CN claimed
CN-119608400-A Targeted barite collector, preparation and application thereof 中国石油天然气集团有限公司 2025-03-14 CN claimed
CN-119607608-A Oil-based rock debris countercurrent extraction agent and preparation and application thereof 中国石油天然气集团有限公司 2025-03-14 CN claimed
CN-119080739-B Synthesis method of 5-chloro-6- (4- (ethoxycarbonyl) piperidin-1-yl) nicotinic acid 深圳智微通科技有限公司 2025-02-25 CN claimed
CN-119462646-A Substituted tetrahydro-beta-carboline derivative, synthesis method and application thereof 江苏科技大学 2025-02-18 CN claimed
US-12208146-B2 Reconstituted HDL nanoparticles for delivery of radioactive agents and uses thereof UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER (US) 2025-01-28 US claimed
CN-119120435-A Nitrilase mutant capable of reducing selectivity of 5-chloronicotinonitrile and improving selectivity of 6-chloronicotinonitrile and application thereof 浙江工业大学 2024-12-13 CN claimed
CN-119102108-A Functional plant fiber fabric and manufacturing process thereof 广西同益新丝绸纺织科技有限公司 2024-12-10 CN claimed
CN-119080739-A Synthesis method of 5-chloro-6- (4- (ethoxycarbonyl) piperidin-1-yl) nicotinic acid 深圳智微通科技有限公司 2024-12-06 CN claimed
WO-1998033786-A1 ACCELERATED CATALYSIS OF OLEFINIC EPOXIDATIONS THE SCRIPPS RESEARCH INSTITUTE (US) 1998-08-06 WO claimed
US-5659042-A Method for preparing esters of halonicotinic acids ALLERGAN (US) 1997-08-19 US claimed
EP-0788482-A1 METHOD FOR PREPARING ESTERS OF HALONICOTINIC ACIDS Allergan (US) 1997-08-13 EP claimed
WO-1996012701-A1 METHOD FOR PREPARING ESTERS OF HALONICOTINIC ACIDS ALLERGAN (US) 1996-05-02 WO claimed
US-5510490-A Process for the preparation of epibatidine COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 1996-04-23 US claimed
US-5430049-A Treating hyperproliferative disorders GAUT ZANE N (US) 1995-07-04 US claimed
EP-0092117-B1 PROCESS FOR PRODUCING CHLORONICOTINIC ACID COMPOUNDS ISHIHARA SANGYO KAISHA, LTD. (JP) 1987-07-15 EP claimed
US-4504665-A Process for producing chloronicotinic acid compounds ISHIHARA SANGYO KAISHA LTD. (JP) 1985-03-12 US claimed
EP-0092117-A1 Process for producing chloronicotinic acid compounds ISHIHARA SANGYO KAISHA, LTD. (JP) 1983-10-26 EP claimed
EP-0024172-B1 ANTITUMOR AND IMMUNOSUPPRESSIVE 4-CARBAMOYLIMIDAZOLIUM-5-OLATE DERIVATIVES, PHARMACEUTICAL COMPOSITION AND PRODUCTION THEREOF SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1983-05-11 EP claimed