Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10556431 | 0.94 | HTR2A (0.47) | HTR2AKMT2AMEN1MAPTALDH1A1 | |
| Oxalic Acid SCHEMBL10460538 | 0.92 | MAOB (0.49) | HTR2AHRH3KMT2AMEN1MAPT | |
| SCHEMBL10460596 | 0.89 | MAOB (0.49) | HTR2AMAPTDRD3 | |
| Oxalic Acid SCHEMBL10460714 | 0.87 | KDM4E (0.53) | HTR2AHRH3KMT2AMEN1KDM4E | |
| SCHEMBL10555930 | 0.87 | DRD3 (0.50) | HRH3KMT2AMEN1POLBMAPT | |
| Oxalic Acid SCHEMBL10460873 | 0.86 | ABCB11 (0.58) | HTR2AKMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL7434723 | 0.85 | ABCB11 (0.51) | HTR2AKMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL10461710 | 0.85 | ABCB11 (0.52) | HTR2AKMT2AMEN1KDM4EALDH1A1 | |
| Oxalic Acid SCHEMBL10461601 | 0.85 | MEN1 (0.62) | HTR2AHRH3KMT2AMEN1KDM4E | |
| SCHEMBL7440618 | 0.84 | ABCB11 (0.46) | HTR2AKDM4EALDH1A1DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4950674-A | Arylalkylheterocyclic amines,N-substituted by aryloxyalkyl group in a method for allergy treatment | A. H. ROBINS COMPANY, INCORPORATED (US) | 1990-08-21 | — | — | US | disclosed |
| US-4810713-A | Arylalkyl-heterocyclic amines, n-substituted by aryloxyalkyl groups used in a method for allergy treatment | A. H. ROBINS COMPANY, INCORPORATED (US) | 1989-03-07 | — | — | US | disclosed |
| EP-0235463-A2 | N-substituted-arylalkyl and arylalkylene piperidines as cardiovascular antihistaminic and antisecretory agents | A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) (US) | 1987-09-09 | — | — | EP | disclosed |