Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 1.00 |
| ▸ | HTR2C | P28335 | 1/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 1/20 | 1.00 |
| ▸ | HTR6 | P50406 | 3/20 | 0.56 |
| ▸ | HTR7 | P34969 | 3/20 | 0.56 |
| ▸ | HTR1A | P08908 | 2/20 | 0.56 |
| ▸ | NCF1 | P14598 | 2/20 | 0.56 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.56 |
| ▸ | HTR3B | O95264 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | HTR1D | P28221 | 1/20 | 0.56 |
| ▸ | HTR1B | P28222 | 1/20 | 0.56 |
| ▸ | MTOR | P42345 | 1/20 | 0.56 |
| ▸ | HTR3A | P46098 | 1/20 | 0.56 |
| ▸ | HTR5A | P47898 | 1/20 | 0.56 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.56 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1048620 | 0.98 | HTR2A (0.97) | HTR2AHTR2CSLC6A4HTR6HTR7 | |
| Methyl Alcohol SCHEMBL27731985 | 0.95 | HTR2A (0.91) | HTR2AHTR2CSLC6A4HTR6HTR7 | |
| SCHEMBL7515421 | 0.94 | HTR2A (0.88) | HTR2AHTR2CSLC6A4HTR6HTR7 | |
| SCHEMBL8961462 | 0.84 | HTR2A (0.73) | HTR2AHTR2CSLC6A4HTR6HTR7 | |
| SCHEMBL29746904 | 0.84 | HTR2A (0.73) | HTR2AHTR2CSLC6A4HTR6HTR7 | |
| SCHEMBL9673340 | 0.83 | HTR2A (0.71) | HTR2AHTR2CSLC6A4HTR6HTR7 | |
| SCHEMBL6639825 | 0.83 | HTR2A (0.70) | HTR2AHTR2CSLC6A4HTR6HTR7 | |
| SCHEMBL3561450 | 0.81 | SLC6A4 (0.68) | HTR2AHTR2CSLC6A4HTR6HTR7 | |
| SCHEMBL10495676 | 0.81 | HTR2C (0.68) | HTR2AHTR2CSLC6A4HTR7HTR1A | |
| SCHEMBL6636331 | 0.80 | HTR2A (0.67) | HTR2AHTR2CSLC6A4HTR6HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 168 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11464759-B2 | 5-HT6 receptor antagonists for use in the treatment of alzheimer's disease in patient subpopulation carrying APOE4 alleles | H. LUNDBECK A/S (DK) | 2022-10-11 | — | — | US | disclosed |
| CN-109069466-B | 5-HT6Receptor antagonists for the treatment of Alzheimer's disease with apathy comorbidity | H.隆德贝克有限公司 | 2021-06-15 | — | — | CN | disclosed |
| EP-3630098-B1 | COMBINATION OF A 5-HT6 RECEPTOR ANTAGONIST AND AN ACETYLCHOLINESTERASE INHIBITOR FOR USE IN THE TREATMENT OF ALZHEIMER'S DISEASE IN A PATIENT SUBPOPULATION CARRYING APOE4 ALLELES | H LUNDBECK AS (DK) | 2021-03-24 | — | — | EP | disclosed |
| US-10864191-B2 | 5-HT6 receptor antagonists for use in the treatment of Alzheimer's disease with apathy as comorbidity | H. LUNDBECK A/S (DK) | 2020-12-15 | — | — | US | disclosed |
| EP-3454848-B1 | 5HT6 RECEPTOR ANTAGONISTS FOR USE IN THE TREATMENT OF ALZHEIMER'S DISEASE WITH APATHY AS COMORBIDITY | H LUNDBECK AS (DK) | 2020-09-09 | — | — | EP | disclosed |
| CN-111032038-A | Pharmaceutical combination for the treatment of alzheimer's disease | H.隆德贝克有限公司 | 2020-04-17 | — | — | CN | disclosed |
| EP-3630098-A1 | COMBINATION OF A 5-HT6 RECEPTOR ANTAGONIST AND AN ACETYLCHOLINESTERASE INHIBITOR FOR USE IN THE TREATMENT OF ALZHEIMER'S DISEASE IN A PATIENT SUBPOPULATION CARRYING APOE4 ALLELES | H. Lundbeck A/S (DK) | 2020-04-08 | — | — | EP | disclosed |
| EP-3454848-A1 | 5HT6 RECEPTOR ANTAGONISTS FOR USE IN THE TREATMENT OF ALZHEIMER'S DISEASE WITH APATHY AS COMORBIDITY | H. Lundbeck A/S (DK) | 2019-03-20 | — | — | EP | disclosed |
| CN-109069466-A | 5-HT6Receptor antagonist is for treating Alzheimer disease with apathy comorbidity | H.隆德贝克有限公司 | 2018-12-21 | — | — | CN | disclosed |
| US-20180353477-A1 | 5-HT6 RECEPTOR ANTAGONISTS FOR USE IN THE TREATMENT OF ALZHEIMER'S DISEASE IN PATIENT SUBPOPULATION CARRYING APOE4 ALLELES | H. LUNDBECK A/S (DK) | 2018-12-13 | — | — | US | disclosed |
| US-4883795-A | Piperazinyl-heterocyclic compounds | PFIZER INC. (US) | 1989-11-28 | — | — | US | disclosed |
| US-4833142-A | Blood-pressure lowering 4-bicyclic-1-piperazinyl-alkyl amides | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 1989-05-23 | — | — | US | disclosed |
| US-4831031-A | Aryl piperazinyl-(C2 or C4) alkylene heterocyclic compounds having neuroleptic activity | PFIZER INC. (US) | 1989-05-16 | — | — | US | disclosed |
| CN-88100986-A | Aryl piperazinyl-alkylene phenyl base-heterogeneous ring compound | — | 1988-09-21 | — | — | CN | disclosed |
| CN-88101642-A | Piperazinyl-heterogeneous ring compound | — | 1988-09-14 | — | — | CN | disclosed |
| EP-0281309-A1 | Piperazinyl-heterocyclic compounds | PFIZER INC. (US) | 1988-09-07 | — | — | EP | disclosed |
| EP-0279598-A2 | Arylpiperazinyl-alkylene-phenyl-heterocyclic compounds | PFIZER INC. (US) | 1988-08-24 | — | — | EP | disclosed |
| EP-0138280-B1 | BLOOD-PRESSURE LOWERING PIPERAZINE DERIVATIVES | DUPHAR INTERNATIONAL RESEARCH B.V (NL) | 1988-06-08 | — | — | EP | disclosed |
| EP-0189612-A1 | New pharmaceutical compositions having a psychotropic activity | DUPHAR INTERNATIONAL RESEARCH B.V (NL) | 1986-08-06 | — | — | EP | disclosed |
| EP-0138280-A2 | Blood-pressure lowering piperazine derivatives | DUPHAR INTERNATIONAL RESEARCH B.V (NL) | 1985-04-24 | — | — | EP | disclosed |