Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXA2R | P21731 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | SYK | P43405 | 9/20 | 0.41 |
| ▸ | STAT6 | P42226 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ITK | Q08881 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10460903 | 0.89 | TBXA2R (0.62) | TBXA2RKDM4ECYP3A4CYP2C9HIF1A | |
| SCHEMBL10462359 | 0.79 | EGFR (0.52) | EGFRTP53MAPTSYKAURKB | |
| SCHEMBL10463578 | 0.79 | EGFR (0.56) | EGFRTP53MAPTSYKAURKB | |
| Water SCHEMBL10462313 | 0.78 | ALDH1A1 (0.49) | TBXA2RKDM4ECYP3A4CYP2C9HIF1A | |
| SCHEMBL10460997 | 0.77 | TBXA2R (0.61) | TBXA2RKDM4ECYP3A4CYP2C9HIF1A | |
| SCHEMBL10462906 | 0.76 | TBXA2R (0.60) | TBXA2RKDM4ECYP3A4CYP2C9HIF1A | |
| SCHEMBL10463902 | 0.76 | TBXA2R (0.60) | TBXA2RKDM4ECYP3A4CYP2C9HIF1A | |
| SCHEMBL10462933 | 0.74 | TBXA2R (0.58) | TBXA2RKDM4ECYP3A4CYP2C9HIF1A | |
| SCHEMBL10460785 | 0.73 | JAK1 (0.39) | SYKADORA2AKCNH2 | |
| SCHEMBL29433655 | 0.70 | TBXA2R (0.66) | TBXA2RKDM4ECYP3A4CYP2C9HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4853389-A | HYPOTENSIVE AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-08-01 | — | — | US | claimed |
| US-4914203-A | 5 step process for preparing certain 2,4-diamino-5-pyrimidine-sulfonyl ureas | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-04-03 | — | — | US | disclosed |
| US-4853389-A | HYPOTENSIVE AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-08-01 | — | — | US | disclosed |