Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXA2R | P21731 | 6/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.62 |
| ▸ | EGFR | P00533 | 2/20 | 0.46 |
| ▸ | SYK | P43405 | 8/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | STAT6 | P42226 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | ITK | Q08881 | 2/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10460441 | 0.89 | TBXA2R (0.48) | TBXA2RKDM4ECYP3A4CYP2C9HIF1A | |
| Water SCHEMBL10462313 | 0.88 | ALDH1A1 (0.49) | TBXA2RKDM4ECYP3A4CYP2C9HIF1A | |
| SCHEMBL10460997 | 0.87 | TBXA2R (0.61) | TBXA2RKDM4ECYP3A4CYP2C9HIF1A | |
| SCHEMBL10462906 | 0.86 | TBXA2R (0.60) | TBXA2RKDM4ECYP3A4CYP2C9HIF1A | |
| SCHEMBL10463902 | 0.86 | TBXA2R (0.60) | TBXA2RKDM4ECYP3A4CYP2C9HIF1A | |
| SCHEMBL10462933 | 0.85 | TBXA2R (0.58) | TBXA2RKDM4ECYP3A4CYP2C9HIF1A | |
| SCHEMBL29433655 | 0.81 | TBXA2R (0.66) | TBXA2RKDM4ECYP3A4CYP2C9HIF1A | |
| SCHEMBL10462359 | 0.80 | EGFR (0.52) | EGFRSYKTP53MAPTAURKB | |
| SCHEMBL10463578 | 0.79 | EGFR (0.56) | EGFRSYKTP53MAPTAURKB | |
| Torsemide SCHEMBL41184 | 0.76 | TBXA2R (1.00) | TBXA2RKDM4ECYP3A4CYP2C9HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4853389-A | HYPOTENSIVE AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-08-01 | — | — | US | claimed |
| US-4914203-A | 5 step process for preparing certain 2,4-diamino-5-pyrimidine-sulfonyl ureas | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-04-03 | — | — | US | disclosed |
| US-4853389-A | HYPOTENSIVE AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-08-01 | — | — | US | disclosed |