Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | NOTUM | Q6P988 | 7/20 | 0.53 |
| ▸ | F2 | P00734 | 1/20 | 0.49 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | RAD52 | P43351 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17725782 | 0.84 | ALDH1A1 (0.62) | ALDH1A1MAPTLMNAHTTNOTUM | |
| SCHEMBL24769728 | 0.84 | NOTUM (0.58) | ALDH1A1MAPTLMNAHTTNOTUM | |
| SCHEMBL1577735 | 0.79 | MAPT (0.58) | ALDH1A1MAPTLMNAHTTNOTUM | |
| SCHEMBL22637227 | 0.79 | NOTUM (0.53) | ALDH1A1MAPTLMNAHTTNOTUM | |
| SCHEMBL24073776 | 0.79 | NOTUM (0.53) | ALDH1A1MAPTLMNAHTTNOTUM | |
| SCHEMBL15872005 | 0.79 | NOTUM (0.72) | ALDH1A1MAPTLMNAHTTNOTUM | |
| SCHEMBL24073780 | 0.79 | NOTUM (0.49) | ALDH1A1MAPTLMNAHTTNOTUM | |
| SCHEMBL221145 | 0.79 | ALDH1A1 (0.56) | ALDH1A1MAPTLMNAHTTNOTUM | |
| SCHEMBL24073374 | 0.78 | NOTUM (0.47) | ALDH1A1MAPTLMNAHTTNOTUM | |
| SCHEMBL19398295 | 0.77 | ALDH1A1 (0.54) | ALDH1A1MAPTLMNAHTTNOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012129452-A2 | PROPYNOIC ACID CARBAMOYL METHYL-ALMIDES AND PHARMACEUTICAL COMPOSITIONS AND METHODS BASED THEREON | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2012-09-27 | — | — | WO | disclosed |
| US-4900839-A | SUBSTITUTED PHENYLPROPENAMIDES | PFIZER INC. (US) | 1990-02-13 | — | — | US | disclosed |
| US-4837334-A | Precursors to quinolone inotropic agents | PFIZER INC. (US) | 1989-06-06 | — | — | US | disclosed |
| US-4728653-A | CONGESTIVE HEART FAILURE | PFIZER INC. (US) | 1988-03-01 | — | — | US | disclosed |