Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 6/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 5/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.38 |
| ▸ | DRD2 | P14416 | 3/20 | 0.38 |
| ▸ | DRD4 | P21917 | 3/20 | 0.38 |
| ▸ | DRD3 | P35462 | 3/20 | 0.38 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | FPR3 | P25089 | 1/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 1/20 | 0.38 |
| ▸ | HTR1B | P28222 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10766081 | 0.90 | ADRB2 (0.38) | BCHEADRB2ADRB1DRD2DRD4 | |
| SCHEMBL10465465 | 0.87 | BACE1 (0.39) | BCHEADRB2ADRB1ADRB3KMT2A | |
| SCHEMBL9574255 | 0.85 | FOLH1 (0.41) | BCHEADRB2ADRB1DRD2DRD4 | |
| SCHEMBL10465045 | 0.83 | ADRB2 (0.42) | BCHEADRB2ADRB1DRD2DRD4 | |
| SCHEMBL10463962 | 0.83 | MRGPRX4 (0.40) | BCHEADRB2ADRB1DRD2DRD4 | |
| SCHEMBL10464981 | 0.81 | ADRB2 (0.43) | BCHEADRB2ADRB1DRD2DRD4 | |
| SCHEMBL10465029 | 0.81 | ADRB2 (0.40) | BCHEADRB2ADRB1DRD2DRD4 | |
| SCHEMBL10478216 | 0.81 | NR1H3 (0.45) | BCHEMEN1KMT2AMAOB | |
| SCHEMBL10464521 | 0.80 | ADRB2 (0.46) | ADRB2ADRB1DRD2DRD4DRD3 | |
| SCHEMBL5279069 | 0.80 | ADRB2 (0.38) | ADRB2ADRB1ADRB3MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4908386-A | Pharmaceuticals | GLAXO GROUP LIMITED (GB) | 1990-03-13 | — | — | US | disclosed |
| EP-0220054-A2 | Ethanolamine derivatives | GLAXO GROUP LIMITED (GB) | 1987-04-29 | — | — | EP | disclosed |